3zgc: Difference between revisions
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{{STRUCTURE_3zgc| PDB=3zgc | SCENE= }} | |||
===crystal structure of the KEAP1-NEH2 complex=== | |||
{{ABSTRACT_PUBMED_23722832}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/NF2L2_HUMAN NF2L2_HUMAN]] Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.<ref>PMID:11035812</ref> | |||
==About this Structure== | |||
[[3zgc]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZGC OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023722832</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Hoerer, S.]] | |||
[[Category: Hoevels, Y.]] | |||
[[Category: Nar, H.]] | |||
[[Category: Ostmann, K.]] | |||
[[Category: Reinert, D.]] | |||
[[Category: Protein-peptide complex]] | |||
[[Category: Transcription]] | |||
Revision as of 15:55, 19 June 2013
crystal structure of the KEAP1-NEH2 complex
Template:ABSTRACT PUBMED 23722832
Function
[NF2L2_HUMAN] Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.[1]
About this Structure
3zgc is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Horer S, Reinert D, Ostmann K, Hoevels Y, Nar H. Crystal-contact engineering to obtain a crystal form of the Kelch domain of human Keap1 suitable for ligand-soaking experiments. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Jun;69(Pt 6):592-6. doi:, 10.1107/S174430911301124X. Epub 2013 May 23. PMID:23722832 doi:10.1107/S174430911301124X
- ↑ Huang HC, Nguyen T, Pickett CB. Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2. Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12475-80. PMID:11035812 doi:https://dx.doi.org/10.1073/pnas.220418997
