1t7j: Difference between revisions

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[[Image:1t7j.gif|left|200px]]<br /><applet load="1t7j" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1t7j.gif|left|200px]]
caption="1t7j, resolution 2.20&Aring;" />
 
'''crystal structure of inhibitor amprenavir in complex with a multi-drug resistant variant of HIV-1 protease (L63P/V82T/I84V)'''<br />
{{Structure
|PDB= 1t7j |SIZE=350|CAPTION= <scene name='initialview01'>1t7j</scene>, resolution 2.20&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene> and <scene name='pdbligand=478:{3-[(4-AMINO-BENZENESULFONYL)-ISOBUTYL-AMINO]-1-BENZYL-2-HYDROXY-PROPYL}-CARBAMIC ACID TETRAHYDRO-FURAN-3-YL ESTER'>478</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16]
|GENE= POL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])
}}
 
'''crystal structure of inhibitor amprenavir in complex with a multi-drug resistant variant of HIV-1 protease (L63P/V82T/I84V)'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1T7J is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=ACT:'>ACT</scene> and <scene name='pdbligand=478:'>478</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T7J OCA].  
1T7J is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T7J OCA].  


==Reference==
==Reference==
Discovery and selection of TMC114, a next generation HIV-1 protease inhibitor., Surleraux DL, Tahri A, Verschueren WG, Pille GM, de Kock HA, Jonckers TH, Peeters A, De Meyer S, Azijn H, Pauwels R, de Bethune MP, King NM, Prabu-Jeyabalan M, Schiffer CA, Wigerinck PB, J Med Chem. 2005 Mar 24;48(6):1813-22. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15771427 15771427]
Discovery and selection of TMC114, a next generation HIV-1 protease inhibitor., Surleraux DL, Tahri A, Verschueren WG, Pille GM, de Kock HA, Jonckers TH, Peeters A, De Meyer S, Azijn H, Pauwels R, de Bethune MP, King NM, Prabu-Jeyabalan M, Schiffer CA, Wigerinck PB, J Med Chem. 2005 Mar 24;48(6):1813-22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15771427 15771427]
[[Category: HIV-1 retropepsin]]
[[Category: HIV-1 retropepsin]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
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[[Category: hiv-1 protease]]
[[Category: hiv-1 protease]]
[[Category: substrate envelope]]
[[Category: substrate envelope]]
[[Category: thermodynamics]]
[[Category: thermodynamic]]


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