Sandbox Reserved 717: Difference between revisions
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The receptor-binding domain can be sub-divided into head and bonnet. On the border between these two subdomains there is a metal-binding site <ref name=r3>PMID: 12888344</ref>. This site binds presumably to zinc. <scene name='Sandbox_Reserved_717/Mynewscene/3'>Two His amino acids </scene> (<scene name='Sandbox_Reserved_717/Mynewscene/1'>His445</scene> and <scene name='Sandbox_Reserved_717/Mynewscene/2'>His447</scene>) from each monomere are octahedrally coordinated around the zinc. | The receptor-binding domain can be sub-divided into head and bonnet. On the border between these two subdomains there is a metal-binding site <ref name=r3>PMID: 12888344</ref>. This site binds presumably to zinc. <scene name='Sandbox_Reserved_717/Mynewscene/3'>Two His amino acids </scene> (<scene name='Sandbox_Reserved_717/Mynewscene/1'>His445</scene> and <scene name='Sandbox_Reserved_717/Mynewscene/2'>His447</scene>) from each monomere are octahedrally coordinated around the zinc. | ||
The receptor-binding domain can be compared to a flower bud. This flower bud has got 12 petals which are organised in a 3-fold symmetry | The receptor-binding domain can be compared to a flower bud. This flower bud has got 12 petals which are organised in a 3-fold symmetry <ref name=r3>PMID: 12888344</ref>. At the bottom there are the residues 406-432 they form the <scene name='Sandbox_Reserved_717/Mynewscene/4'>first petal </scene> , just above there are the residues 489-504 which form the <scene name='Sandbox_Reserved_717/Mynewscene/5'>second petal</scene> . The <scene name='Sandbox_Reserved_717/Mynewscene/6'>third petal </scene> is formed by the residues 450-470 and at the top there are the residues 470-480 and form the <scene name='Sandbox_Reserved_717/Mynewscene/7'>fourth petal</scene> . The complete and active receptor-binding domain is built by the trimeric protein. This trimeric proteine structure is stabilised by many inter-domain hydrogen bounds <ref name=r3>PMID: 12888344</ref>. These hydrogen bounds can have the profiles: main-chain-main-chain, main-chain-side-chain and side-chain-side-chain. | ||
==='''The LPS-Bindind Site''' <ref name=r3>PMID: 12888344</ref>=== | ==='''The LPS-Bindind Site''' <ref name=r3>PMID: 12888344</ref>=== | ||
