1tft: Difference between revisions

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[[Image:1tft.gif|left|200px]]<br /><~~applet load~~=~~"1tft" size~~=~~"350" color~~=~~"white" frame~~=~~"true" align="right" spinBox~~=~~"true"~~

[[Image:1tft.gif|left|200px]]

~~caption~~=~~"1tft"~~ />

'''NMR Structure of an Antagonists of the XIAP-Caspase-9 Interaction Complexed to the BIR3 domain of XIAP'''~~<br />~~

{{Structure

|PDB= 1tft |SIZE=350|CAPTION= <scene name='initialview01'>1tft</scene>

|SITE=

|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=997:1-[3,3-DIMETHYL-2-(2-METHYLAMINO-PROPIONYLAMINO)-BUTYRYL]-4-PHENOXY-PYRROLIDINE-2-CARBOXYLIC ACID(1,2,3,4-TETRAHYDRO-NAPHTHALEN-1-YL)-AMIDE'>997</scene>

|ACTIVITY=

|GENE= BIRC4, API3, IAP3, XIAP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])

}}

'''NMR Structure of an Antagonists of the XIAP-Caspase-9 Interaction Complexed to the BIR3 domain of XIAP'''

==Overview==

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==About this Structure==

1TFT is a [~~http://en.wikipedia.org/wiki/Single_protein~~ Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens~~] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=997:'>997</scene> as [http://en.wikipedia.org/wiki/ligands ligands~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TFT OCA].

1TFT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TFT OCA].

==Reference==

Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer., Oost TK, Sun C, Armstrong RC, Al-Assaad AS, Betz SF, Deckwerth TL, Ding H, Elmore SW, Meadows RP, Olejniczak ET, Oleksijew A, Oltersdorf T, Rosenberg SH, Shoemaker AR, Tomaselli KJ, Zou H, Fesik SW, J Med Chem. 2004 Aug 26;47(18):4417-26. PMID:[http://~~ispc~~.~~weizmann~~.ac.~~il/~~/~~pmbin~~/~~getpm?pmid=~~15317454 15317454]

Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer., Oost TK, Sun C, Armstrong RC, Al-Assaad AS, Betz SF, Deckwerth TL, Ding H, Elmore SW, Meadows RP, Olejniczak ET, Oleksijew A, Oltersdorf T, Rosenberg SH, Shoemaker AR, Tomaselli KJ, Zou H, Fesik SW, J Med Chem. 2004 Aug 26;47(18):4417-26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15317454 15317454]

[[Category: Homo sapiens]]

[[Category: Single protein]]

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[[Category: xiap]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:17:50 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1tft.gif|left|200px]]<br /><applet load="1tft" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1tft.gif|left|200px]]
-caption="1tft" />
-'''NMR Structure of an Antagonists of the XIAP-Caspase-9 Interaction Complexed to the BIR3 domain of XIAP'''<br />
+ {{Structure
+|PDB= 1tft |SIZE=350|CAPTION= <scene name='initialview01'>1tft</scene>
+|SITE=
+|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=997:1-[3,3-DIMETHYL-2-(2-METHYLAMINO-PROPIONYLAMINO)-BUTYRYL]-4-PHENOXY-PYRROLIDINE-2-CARBOXYLIC ACID(1,2,3,4-TETRAHYDRO-NAPHTHALEN-1-YL)-AMIDE'>997</scene>
+|ACTIVITY=
+|GENE= BIRC4, API3, IAP3, XIAP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+}}
+'''NMR Structure of an Antagonists of the XIAP-Caspase-9 Interaction Complexed to the BIR3 domain of XIAP'''
 ==Overview==
@@ Line 10: / Line 19: @@
 ==About this Structure==
-TFT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=997:'>997</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TFT OCA].
+TFT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TFT OCA].
 ==Reference==
-Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer., Oost TK, Sun C, Armstrong RC, Al-Assaad AS, Betz SF, Deckwerth TL, Ding H, Elmore SW, Meadows RP, Olejniczak ET, Oleksijew A, Oltersdorf T, Rosenberg SH, Shoemaker AR, Tomaselli KJ, Zou H, Fesik SW, J Med Chem. 2004 Aug 26;47(18):4417-26. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15317454 15317454]
+Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer., Oost TK, Sun C, Armstrong RC, Al-Assaad AS, Betz SF, Deckwerth TL, Ding H, Elmore SW, Meadows RP, Olejniczak ET, Oleksijew A, Oltersdorf T, Rosenberg SH, Shoemaker AR, Tomaselli KJ, Zou H, Fesik SW, J Med Chem. 2004 Aug 26;47(18):4417-26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15317454 15317454]
 [[Category: Homo sapiens]]
 [[Category: Single protein]]
@@ Line 39: / Line 48: @@
 [[Category: xiap]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:13:03 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:17:50 2008''