Sandbox Reserved 704: Difference between revisions

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4) The <scene name='Sandbox_Reserved_704/Domain_4/1'>CP1 editing domain</scene> is located in the middle of the CP1 hairpin. It is the editing domain, that means that this region is responsible for the hydrolysis of the incorrectly synthesized products. Because LeuRS have a specific editing activity that hydrolyzes misactivated aminoacyl-adenylates (pre-transfer editing) and mischarged aminoacyl-tRNAs (post-transfer editing) or both when they have misformed with noncognate amino acids.The <scene name='Sandbox_Reserved_704/Asp332/1'>residue Asp 332</scene> is necessary for post-transfer editing <ref name="Fukunaga">PMID:15663927</ref>.

5) The <scene name='Sandbox_Reserved_704/Domain_5/1'>CP2 domain</scene> is inserted between the second and third β-sheets of the CP core. It is composed of a pair of antiparallel α-helices and a connecting β-sheet and is necessary for the amino acid activation and post-transfer editing <ref name="">PMID:18955487</ref>.

5) The <scene name='Sandbox_Reserved_704/Domain_5/1'>CP2 domain</scene> is inserted between the second and third β-sheets of the CP core. It is composed of a pair of antiparallel α-helices and a connecting β-sheet and is necessary for the amino acid activation and post-transfer editing <ref name="Zhou XL,Zhu B">PMID:18955487</ref>.

Sandbox Reserved 704: Difference between revisions

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Revision as of 13:59, 3 January 2013 view source Perrine Faiderbe (talk \| contribs) 45 edits No edit summary ← Older edit		Revision as of 14:02, 3 January 2013 view source Perrine Faiderbe (talk \| contribs) 45 edits No edit summary Newer edit →
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	4) The <scene name='Sandbox_Reserved_704/Domain_4/1'>CP1 editing domain</scene> is located in the middle of the CP1 hairpin. It is the editing domain, that means that this region is responsible for the hydrolysis of the incorrectly synthesized products. Because LeuRS have a specific editing activity that hydrolyzes misactivated aminoacyl-adenylates (pre-transfer editing) and mischarged aminoacyl-tRNAs (post-transfer editing) or both when they have misformed with noncognate amino acids.The <scene name='Sandbox_Reserved_704/Asp332/1'>residue Asp 332</scene> is necessary for post-transfer editing <ref name="Fukunaga">PMID:15663927</ref>.		4) The <scene name='Sandbox_Reserved_704/Domain_4/1'>CP1 editing domain</scene> is located in the middle of the CP1 hairpin. It is the editing domain, that means that this region is responsible for the hydrolysis of the incorrectly synthesized products. Because LeuRS have a specific editing activity that hydrolyzes misactivated aminoacyl-adenylates (pre-transfer editing) and mischarged aminoacyl-tRNAs (post-transfer editing) or both when they have misformed with noncognate amino acids.The <scene name='Sandbox_Reserved_704/Asp332/1'>residue Asp 332</scene> is necessary for post-transfer editing <ref name="Fukunaga">PMID:15663927</ref>.

	5) The <scene name='Sandbox_Reserved_704/Domain_5/1'>CP2 domain</scene> is inserted between the second and third β-sheets of the CP core. It is composed of a pair of antiparallel α-helices and a connecting β-sheet and is necessary for the amino acid activation and post-transfer editing <ref name="">PMID:18955487</ref>.		5) The <scene name='Sandbox_Reserved_704/Domain_5/1'>CP2 domain</scene> is inserted between the second and third β-sheets of the CP core. It is composed of a pair of antiparallel α-helices and a connecting β-sheet and is necessary for the amino acid activation and post-transfer editing <ref name="Zhou XL,Zhu B">PMID:18955487</ref>.