1tg2: Difference between revisions

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[[Image:1tg2.jpg|left|200px]]<br /><applet load="1tg2" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1tg2.jpg|left|200px]]
caption="1tg2, resolution 2.20&Aring;" />
 
'''Crystal structure of phenylalanine hydroxylase A313T mutant with 7,8-dihydrobiopterin bound'''<br />
{{Structure
|PDB= 1tg2 |SIZE=350|CAPTION= <scene name='initialview01'>1tg2</scene>, resolution 2.20&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene> and <scene name='pdbligand=H2B:2-AMINO-6-(1,2-DIHYDROXY-PROPYL)-7,8-DIHYDRO-6H-PTERIDIN-4-ONE'>H2B</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Phenylalanine_4-monooxygenase Phenylalanine 4-monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.16.1 1.14.16.1]
|GENE= PAH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Crystal structure of phenylalanine hydroxylase A313T mutant with 7,8-dihydrobiopterin bound'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1TG2 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=FE:'>FE</scene> and <scene name='pdbligand=H2B:'>H2B</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Phenylalanine_4-monooxygenase Phenylalanine 4-monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.16.1 1.14.16.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TG2 OCA].  
1TG2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TG2 OCA].  


==Reference==
==Reference==
Correction of kinetic and stability defects by tetrahydrobiopterin in phenylketonuria patients with certain phenylalanine hydroxylase mutations., Erlandsen H, Pey AL, Gamez A, Perez B, Desviat LR, Aguado C, Koch R, Surendran S, Tyring S, Matalon R, Scriver CR, Ugarte M, Martinez A, Stevens RC, Proc Natl Acad Sci U S A. 2004 Nov 30;101(48):16903-8. Epub 2004 Nov 19. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15557004 15557004]
Correction of kinetic and stability defects by tetrahydrobiopterin in phenylketonuria patients with certain phenylalanine hydroxylase mutations., Erlandsen H, Pey AL, Gamez A, Perez B, Desviat LR, Aguado C, Koch R, Surendran S, Tyring S, Matalon R, Scriver CR, Ugarte M, Martinez A, Stevens RC, Proc Natl Acad Sci U S A. 2004 Nov 30;101(48):16903-8. Epub 2004 Nov 19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15557004 15557004]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Phenylalanine 4-monooxygenase]]
[[Category: Phenylalanine 4-monooxygenase]]
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[[Category: phenylalanine hydroxylase phenylketonuria mutant a313t in complex with cofactor analogue 7]]
[[Category: phenylalanine hydroxylase phenylketonuria mutant a313t in complex with cofactor analogue 7]]


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