1s9b: Difference between revisions

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[[~~Image~~:1s9b.~~png|left|200px~~]]

==Crystal Structure Analysis of the B-DNA GAATTCG==

== Structural highlights ==

<table><tr><td colspan='2'>[[1s9b]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S9B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1S9B FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s9b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1s9b RCSB], [http://www.ebi.ac.uk/pdbsum/1s9b PDBsum]</span></td></tr>

</table>

== Publication Abstract from PubMed ==

DNA oligonucleotides can be used in order to assemble highly structured materials. Oligonucleotides with sticky ends can form long linear structures, whereas branching is required to form two- and three-dimensional nanostructures. In this paper, we show that when Ni(2+) is attached to the N7 atom of guanine, it can also act as a branching point. Thus, we have found that the heptanucleotide d(GAATTCG) can assemble into long linear duplex structures, which cross in space to generate a cubic structure. The three-dimensional arrays are stabilized by phosphate-Ni(2+)-guanine interactions. For the first time, the crystallization of a B form DNA oligonucleotide in a cubic system is reported, space group I23. Large solvent cavities are found among the DNA duplexes.

~~{{STRUCTURE_1s9b| PDB=1s9b | SCENE= }}~~

A cubic arrangement of DNA double helices based on nickel-guanine interactions.,Valls N, Uson I, Gouyette C, Subirana JA J Am Chem Soc. 2004 Jun 30;126(25):7812-6. PMID:15212528<ref>PMID:15212528</ref>

~~===Crystal Structure Analysis~~ of the ~~B-DNA GAATTCG===~~

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

</div>

~~{{ABSTRACT_PUBMED_15212528}}~~

== References ==

==~~About this Structure~~==

__TOC__

~~[[1s9b]] is a 2 chain structure. Full crystallographic information is available from [http:~~//~~oca.weizmann.ac.il/oca-bin/ocashort?id=1S9B OCA].~~

</StructureSection>

[[Category: Gouyette, C.]]

[[Category: Subirana, J A.]]

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@@ Line 1: / Line 1: @@
-[[Image:1s9b.png|left|200px]]
+==Crystal Structure Analysis of the B-DNA GAATTCG==
+<StructureSection load='1s9b' size='340' side='right' caption='[[1s9b]], [[Resolution|resolution]] 2.81&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1s9b]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S9B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1S9B FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s9b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1s9b RCSB], [http://www.ebi.ac.uk/pdbsum/1s9b PDBsum]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+DNA oligonucleotides can be used in order to assemble highly structured materials. Oligonucleotides with sticky ends can form long linear structures, whereas branching is required to form two- and three-dimensional nanostructures. In this paper, we show that when Ni(2+) is attached to the N7 atom of guanine, it can also act as a branching point. Thus, we have found that the heptanucleotide d(GAATTCG) can assemble into long linear duplex structures, which cross in space to generate a cubic structure. The three-dimensional arrays are stabilized by phosphate-Ni(2+)-guanine interactions. For the first time, the crystallization of a B form DNA oligonucleotide in a cubic system is reported, space group I23. Large solvent cavities are found among the DNA duplexes.
-{{STRUCTURE_1s9b|  PDB=1s9b  |  SCENE=  }}
+A cubic arrangement of DNA double helices based on nickel-guanine interactions.,Valls N, Uson I, Gouyette C, Subirana JA J Am Chem Soc. 2004 Jun 30;126(25):7812-6. PMID:15212528<ref>PMID:15212528</ref>
-===Crystal Structure Analysis of the B-DNA GAATTCG===
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-{{ABSTRACT_PUBMED_15212528}}
+== References ==
+<references/>
-==About this Structure==
+__TOC__
-[[1s9b]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S9B OCA].
+</StructureSection>
 [[Category: Gouyette, C.]]
 [[Category: Subirana, J A.]]