1thl: Difference between revisions

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[[Image:1thl.jpg|left|200px]]<br /><applet load="1thl" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1thl.jpg|left|200px]]
caption="1thl, resolution 1.70&Aring;" />
 
'''Thermolysin complexed with a novel glutaramide derivative, n-(1-(2(r,s)-carboxy-4-phenylbutyl) cyclopentylcarbonyl)-(s)-tryptophan'''<br />
{{Structure
|PDB= 1thl |SIZE=350|CAPTION= <scene name='initialview01'>1thl</scene>, resolution 1.70&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene>, <scene name='pdbligand=CLT:4-PHENYL-BUTANOIC+ACID'>CLT</scene> and <scene name='pdbligand=CCM:1-METHYL-1-CARBOXY-CYCLOPENTANE'>CCM</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Thermolysin Thermolysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.27 3.4.24.27]
|GENE=
}}
 
'''Thermolysin complexed with a novel glutaramide derivative, n-(1-(2(r,s)-carboxy-4-phenylbutyl) cyclopentylcarbonyl)-(s)-tryptophan'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1THL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_thermoproteolyticus Bacillus thermoproteolyticus] with <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=TRP:'>TRP</scene>, <scene name='pdbligand=CLT:'>CLT</scene> and <scene name='pdbligand=CCM:'>CCM</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Thermolysin Thermolysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.27 3.4.24.27] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1THL OCA].  
1THL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_thermoproteolyticus Bacillus thermoproteolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1THL OCA].  


==Reference==
==Reference==
Inhibition of thermolysin and neutral endopeptidase 24.11 by a novel glutaramide derivative: X-ray structure determination of the thermolysin-inhibitor complex., Holland DR, Barclay PL, Danilewicz JC, Matthews BW, James K, Biochemistry. 1994 Jan 11;33(1):51-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8286362 8286362]
Inhibition of thermolysin and neutral endopeptidase 24.11 by a novel glutaramide derivative: X-ray structure determination of the thermolysin-inhibitor complex., Holland DR, Barclay PL, Danilewicz JC, Matthews BW, James K, Biochemistry. 1994 Jan 11;33(1):51-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8286362 8286362]
[[Category: Bacillus thermoproteolyticus]]
[[Category: Bacillus thermoproteolyticus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: hydrolase(metalloproteinase)]]
[[Category: hydrolase(metalloproteinase)]]


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