1tl7: Difference between revisions

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[[Image:1tl7.gif|left|200px]]<br /><applet load="1tl7" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1tl7.gif|left|200px]]
caption="1tl7, resolution 2.80&Aring;" />
 
'''Complex Of Gs- With The Catalytic Domains Of Mammalian Adenylyl Cyclase: Complex With 2'(3')-O-(N-methylanthraniloyl)-guanosine 5'-triphosphate and Mn'''<br />
{{Structure
|PDB= 1tl7 |SIZE=350|CAPTION= <scene name='initialview01'>1tl7</scene>, resolution 2.80&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=GSP:5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE'>GSP</scene>, <scene name='pdbligand=FOK:FORSKOLIN'>FOK</scene> and <scene name='pdbligand=ONM:3'-O-(N-METHYLANTHRANILOYL)-GUANOSINE-5'-TRIPHOSPHATE'>ONM</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Adenylate_cyclase Adenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.1 4.6.1.1]
|GENE= Name=ADCY5; ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9615 Canis lupus familiaris]), Name=Adcy2; ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus]), Name=GNAS; Synonyms=GNAS1; ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 Bos taurus])
}}
 
'''Complex Of Gs- With The Catalytic Domains Of Mammalian Adenylyl Cyclase: Complex With 2'(3')-O-(N-methylanthraniloyl)-guanosine 5'-triphosphate and Mn'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1TL7 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=CL:'>CL</scene>, <scene name='pdbligand=MN:'>MN</scene>, <scene name='pdbligand=GSP:'>GSP</scene>, <scene name='pdbligand=FOK:'>FOK</scene> and <scene name='pdbligand=ONM:'>ONM</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Adenylate_cyclase Adenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.1 4.6.1.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TL7 OCA].  
1TL7 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TL7 OCA].  


==Reference==
==Reference==
Structural basis for the inhibition of mammalian membrane adenylyl cyclase by 2 '(3')-O-(N-Methylanthraniloyl)-guanosine 5 '-triphosphate., Mou TC, Gille A, Fancy DA, Seifert R, Sprang SR, J Biol Chem. 2005 Feb 25;280(8):7253-61. Epub 2004 Dec 9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15591060 15591060]
Structural basis for the inhibition of mammalian membrane adenylyl cyclase by 2 '(3')-O-(N-Methylanthraniloyl)-guanosine 5 '-triphosphate., Mou TC, Gille A, Fancy DA, Seifert R, Sprang SR, J Biol Chem. 2005 Feb 25;280(8):7253-61. Epub 2004 Dec 9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15591060 15591060]
[[Category: Adenylate cyclase]]
[[Category: Adenylate cyclase]]
[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: mant-gtp]]
[[Category: mant-gtp]]


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