1tl3: Difference between revisions

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[[Image:1tl3.gif|left|200px]]<br /><applet load="1tl3" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1tl3.gif|left|200px]]
caption="1tl3, resolution 2.80&Aring;" />
 
'''Crystal structure of hiv-1 reverse transcriptase in complex with gw450557'''<br />
{{Structure
|PDB= 1tl3 |SIZE=350|CAPTION= <scene name='initialview01'>1tl3</scene>, resolution 2.80&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene> and <scene name='pdbligand=H20:6-CHLORO-4-(CYCLOHEXYLOXY)-3-ISOPROPYLQUINOLIN-2(1H)-ONE'>H20</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49]
|GENE= Name=POL; ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])
}}
 
'''Crystal structure of hiv-1 reverse transcriptase in complex with gw450557'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1TL3 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=PO4:'>PO4</scene> and <scene name='pdbligand=H20:'>H20</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TL3 OCA].  
1TL3 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TL3 OCA].  


==Reference==
==Reference==
Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 1., Hopkins AL, Ren J, Milton J, Hazen RJ, Chan JH, Stuart DI, Stammers DK, J Med Chem. 2004 Nov 18;47(24):5912-22. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15537346 15537346]
Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 1., Hopkins AL, Ren J, Milton J, Hazen RJ, Chan JH, Stuart DI, Stammers DK, J Med Chem. 2004 Nov 18;47(24):5912-22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15537346 15537346]
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: H20]]
[[Category: H20]]
[[Category: PO4]]
[[Category: PO4]]
[[Category: aids]]
[[Category: aid]]
[[Category: drug design]]
[[Category: drug design]]
[[Category: gw450557]]
[[Category: gw450557]]
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[[Category: nnrti]]
[[Category: nnrti]]


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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:19:47 2008''
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