1tkx: Difference between revisions

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[[Image:1tkx.gif|left|200px]]<br /><applet load="1tkx" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1tkx.gif|left|200px]]
caption="1tkx, resolution 2.85&Aring;" />
 
'''CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW490745'''<br />
{{Structure
|PDB= 1tkx |SIZE=350|CAPTION= <scene name='initialview01'>1tkx</scene>, resolution 2.85&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=GWB:4-[(CYCLOPROPYLETHYNYL)OXY]-6-FLUORO-3-ISOPROPYLQUINOLIN-2(1H)-ONE'>GWB</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49]
|GENE= POL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])
}}
 
'''CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW490745'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1TKX is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=GWB:'>GWB</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TKX OCA].  
1TKX is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TKX OCA].  


==Reference==
==Reference==
Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 2., Freeman GA, Andrews Iii CW 3rd, Hopkins AL, Lowell GS, Schaller LT, Cowan JR, Gonzales SS, Koszalka GW, Hazen RJ, Boone LR, Ferris RG, Creech KL, Roberts GB, Short SA, Weaver K, Reynolds DJ, Milton J, Ren J, Stuart DI, Stammers DK, Chan JH, J Med Chem. 2004 Nov 18;47(24):5923-36. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15537347 15537347]
Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 2., Freeman GA, Andrews Iii CW 3rd, Hopkins AL, Lowell GS, Schaller LT, Cowan JR, Gonzales SS, Koszalka GW, Hazen RJ, Boone LR, Ferris RG, Creech KL, Roberts GB, Short SA, Weaver K, Reynolds DJ, Milton J, Ren J, Stuart DI, Stammers DK, Chan JH, J Med Chem. 2004 Nov 18;47(24):5923-36. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15537347 15537347]
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: Stuart, D I.]]
[[Category: Stuart, D I.]]
[[Category: GWB]]
[[Category: GWB]]
[[Category: aids]]
[[Category: aid]]
[[Category: drug design]]
[[Category: drug design]]
[[Category: gw490745]]
[[Category: gw490745]]
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[[Category: nnrti]]
[[Category: nnrti]]


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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:19:48 2008''
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