1tlc: Difference between revisions

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[[Image:1tlc.gif|left|200px]]<br /><applet load="1tlc" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1tlc.gif|left|200px]]
caption="1tlc, resolution 2.1&Aring;" />
 
'''THYMIDYLATE SYNTHASE COMPLEXED WITH DGMP AND FOLATE ANALOG 1843U89'''<br />
{{Structure
|PDB= 1tlc |SIZE=350|CAPTION= <scene name='initialview01'>1tlc</scene>, resolution 2.1&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=DGP:2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE'>DGP</scene> and <scene name='pdbligand=F89:S)-2-(5(((1,2-DIHYDRO-3-METHYL-1-OXOBENZO(F)QUINAZOLIN-9-YL)METHYL)AMINO)1-OXO-2-ISOINDOLINYL)GLUTARIC ACID'>F89</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45]
|GENE=
}}
 
'''THYMIDYLATE SYNTHASE COMPLEXED WITH DGMP AND FOLATE ANALOG 1843U89'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1TLC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=DGP:'>DGP</scene> and <scene name='pdbligand=F89:'>F89</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TLC OCA].  
1TLC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TLC OCA].  


==Reference==
==Reference==
Promotion of purine nucleotide binding to thymidylate synthase by a potent folate analogue inhibitor, 1843U89., Weichsel A, Montfort WR, Ciesla J, Maley F, Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3493-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7724588 7724588]
Promotion of purine nucleotide binding to thymidylate synthase by a potent folate analogue inhibitor, 1843U89., Weichsel A, Montfort WR, Ciesla J, Maley F, Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3493-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7724588 7724588]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: methyltransferase]]
[[Category: methyltransferase]]


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