1toa: Difference between revisions
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[[Image:1toa.gif|left|200px]] | [[Image:1toa.gif|left|200px]] | ||
'''PERIPLASMIC ZINC BINDING PROTEIN TROA FROM TREPONEMA PALLIDUM''' | {{Structure | ||
|PDB= 1toa |SIZE=350|CAPTION= <scene name='initialview01'>1toa</scene>, resolution 1.8Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene> | |||
|ACTIVITY= | |||
|GENE= | |||
}} | |||
'''PERIPLASMIC ZINC BINDING PROTEIN TROA FROM TREPONEMA PALLIDUM''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1TOA is a [ | 1TOA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Treponema_pallidum Treponema pallidum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TOA OCA]. | ||
==Reference== | ==Reference== | ||
Treponema pallidum TroA is a periplasmic zinc-binding protein with a helical backbone., Lee YH, Deka RK, Norgard MV, Radolf JD, Hasemann CA, Nat Struct Biol. 1999 Jul;6(7):628-33. PMID:[http:// | Treponema pallidum TroA is a periplasmic zinc-binding protein with a helical backbone., Lee YH, Deka RK, Norgard MV, Radolf JD, Hasemann CA, Nat Struct Biol. 1999 Jul;6(7):628-33. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10404217 10404217] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Treponema pallidum]] | [[Category: Treponema pallidum]] | ||
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[[Category: zinc binding protein]] | [[Category: zinc binding protein]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:21:02 2008'' | ||
Revision as of 12:21, 20 March 2008
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| 1toa, resolution 1.8Å | |||||||||||||
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| Ligands: | ZN and GOL | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
PERIPLASMIC ZINC BINDING PROTEIN TROA FROM TREPONEMA PALLIDUM
Overview
The crystal structure of recombinant TroA, a zinc-binding protein component of an ATP-binding cassette transport system in Treponema pallidum, was determined at a resolution of 1.8 A. The organization of the protein is largely similar to other periplasmic ligand-binding proteins (PLBP), in that two independent globular domains interact with each other to create a zinc-binding cleft between them. The structure has one bound zinc pentavalently coordinated to residues from both domains. Unlike previous PLBP structures that have an interdomain hinge composed of beta-strands, the N- and C-domains of TroA are linked by a single long backbone helix. This unique backbone helical conformation was possibly adopted to limit the hinge motion associated with ligand exchange.
About this Structure
1TOA is a Single protein structure of sequence from Treponema pallidum. Full crystallographic information is available from OCA.
Reference
Treponema pallidum TroA is a periplasmic zinc-binding protein with a helical backbone., Lee YH, Deka RK, Norgard MV, Radolf JD, Hasemann CA, Nat Struct Biol. 1999 Jul;6(7):628-33. PMID:10404217
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