1smz: Difference between revisions

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[[~~Image~~:1smz.~~png|left|200px~~]]

==Structure of Transportan in phospholipid bicellar solution==

== Structural highlights ==

<table><tr><td colspan='2'>[[1smz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SMZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SMZ FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1smz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1smz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1smz RCSB], [http://www.ebi.ac.uk/pdbsum/1smz PDBsum]</span></td></tr>

</table>

== Publication Abstract from PubMed ==

Transportan is a chimeric cell-penetrating peptide constructed from the peptides galanin and mastoparan, which has the ability to internalize living cells carrying a hydrophilic load. In this study, we have determined the NMR solution structure and investigated the position of transportan in neutral bicelles. The structure revealed a well-defined alpha-helix in the C-terminal mastoparan part of the peptide and a weaker tendency to form an alpha-helix in the N-terminal domain. The position of the peptide in relation to the membrane, as studied by adding paramagnetic probes, shows that the peptide lies parallel to, and in the head-group region of the membrane surface. This result is supported by amide proton secondary chemical shifts.

~~{{STRUCTURE_1smz| PDB=1smz | SCENE= }}~~

NMR solution structure and position of transportan in neutral phospholipid bicelles.,Barany-Wallje E, Andersson A, Graslund A, Maler L FEBS Lett. 2004 Jun 4;567(2-3):265-9. PMID:15178334<ref>PMID:15178334</ref>

~~===Structure~~ of ~~Transportan in phospholipid bicellar solution===~~

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

</div>

~~{{ABSTRACT_PUBMED_15178334}}~~

== References ==

==~~About this Structure~~==

__TOC__

~~[[1smz]] is a 1 chain structure. Full experimental information is available from [http:~~//~~oca.weizmann.ac.il/oca-bin/ocashort?id=1SMZ OCA].~~

</StructureSection>

[[Category: Andersson, A.]]

[[Category: Barany-Wallje, E.]]

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-[[Image:1smz.png|left|200px]]
+==Structure of Transportan in phospholipid bicellar solution==
+<StructureSection load='1smz' size='340' side='right' caption='[[1smz]], [[NMR_Ensembles_of_Models | 25 NMR models]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1smz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SMZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SMZ FirstGlance]. <br>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1smz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1smz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1smz RCSB], [http://www.ebi.ac.uk/pdbsum/1smz PDBsum]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Transportan is a chimeric cell-penetrating peptide constructed from the peptides galanin and mastoparan, which has the ability to internalize living cells carrying a hydrophilic load. In this study, we have determined the NMR solution structure and investigated the position of transportan in neutral bicelles. The structure revealed a well-defined alpha-helix in the C-terminal mastoparan part of the peptide and a weaker tendency to form an alpha-helix in the N-terminal domain. The position of the peptide in relation to the membrane, as studied by adding paramagnetic probes, shows that the peptide lies parallel to, and in the head-group region of the membrane surface. This result is supported by amide proton secondary chemical shifts.
-{{STRUCTURE_1smz|  PDB=1smz  |  SCENE=  }}
+NMR solution structure and position of transportan in neutral phospholipid bicelles.,Barany-Wallje E, Andersson A, Graslund A, Maler L FEBS Lett. 2004 Jun 4;567(2-3):265-9. PMID:15178334<ref>PMID:15178334</ref>
-===Structure of Transportan in phospholipid bicellar solution===
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-{{ABSTRACT_PUBMED_15178334}}
+== References ==
+<references/>
-==About this Structure==
+__TOC__
-[[1smz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SMZ OCA].
+</StructureSection>
 [[Category: Andersson, A.]]
 [[Category: Barany-Wallje, E.]]