Sandbox Reserved 709: Difference between revisions
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'''NPC'''s ('''Nuclear Pore Complexes''') are composed of many [[Nucleoporin|nucleoporins]] and are heavy proteins assembly. These complexes allow the passive diffusion of ions and the active transport of large molecules such as proteins in both directions. Because of the particular shape of NPCs, transport of large proteins take a lot of time. | '''NPC'''s ('''Nuclear Pore Complexes''') are composed of many [[Nucleoporin|nucleoporins]] and are heavy proteins assembly. These complexes allow the passive diffusion of ions and the active transport of large molecules such as proteins in both directions. Because of the particular shape of NPCs, transport of large proteins take a lot of time. | ||
Thus, proteins over 60 kDa have trouble to pass through them that’s why they need complementary proteins : ''' | Thus, proteins over 60 kDa have trouble to pass through them that’s why they need complementary proteins : '''importins''' to go in the nucleus and '''exportins''' to go out of the nucleus. <ref name="ALBERTS">ALBERTS,B. JOHNSON,A. WALTER,P. LEWIS,J. RAFF,M. ROBERTS,K. (2007). Molecular Biology of the Cell (p. 704-712)</ref> | ||
===Selectivity of nuclear import=== | ===Selectivity of nuclear import=== | ||
