Sandbox Reserved 704: Difference between revisions

Revision as of 17:45, 4 January 2013 view source Marion Vandeputte (talk \| contribs) 20 edits No edit summary ← Older edit		Revision as of 12:11, 5 January 2013 view source Perrine Faiderbe (talk \| contribs) 45 edits No edit summary Newer edit →
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	;The crystal structure of leucyl-tRNA synthetase and tRNA (leucine) complex		;The crystal structure of leucyl-tRNA synthetase and tRNA (leucine) complex

	Aminoacyl-tRNA synthetases (aaRSs) are ligases which exclusively attach a particular amino acid to the 3'-end of its set of cognate tRNAs isoacceptors. It is a two-step reaction : first, an activated intermediate called ~~aminoacyladenylate~~ is synthesized from the amino acid and ATP. Then, the activated amino acid is transferred to the 3’-end of the tRNA. It leads to the formation of the aminoacyl-tRNA. The fidelity of protein synthesis depends on the accuracy of this reaction <ref name="Zhou">PMID:20482517</ref>.		Aminoacyl-tRNA synthetases (aaRSs) are ligases which exclusively attach a particular amino acid to the 3'-end of its set of cognate tRNAs isoacceptors. It is a two-step reaction : first, an activated intermediate called aminoacyl-adenylate is synthesized from the amino acid and ATP. Then, the activated amino acid is transferred to the 3’-end of the tRNA. It leads to the formation of the aminoacyl-tRNA. The fidelity of protein synthesis depends on the accuracy of this reaction <ref name="Zhou">PMID:20482517</ref>.

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