1tq7: Difference between revisions

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[[Image:1tq7.jpg|left|200px]]<br /><applet load="1tq7" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1tq7.jpg|left|200px]]
caption="1tq7, resolution 2.40&Aring;" />
 
'''Crystal structure of the anticoagulant thrombin mutant W215A/E217A bound to PPACK'''<br />
{{Structure
|PDB= 1tq7 |SIZE=350|CAPTION= <scene name='initialview01'>1tq7</scene>, resolution 2.40&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=CH2:METHYLENE GROUP'>CH2</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Thrombin Thrombin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5]
|GENE= F2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Crystal structure of the anticoagulant thrombin mutant W215A/E217A bound to PPACK'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1TQ7 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene>, <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=CH2:'>CH2</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Thrombin Thrombin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TQ7 OCA].  
1TQ7 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TQ7 OCA].  


==Reference==
==Reference==
The anticoagulant thrombin mutant W215A/E217A has a collapsed primary specificity pocket., Pineda AO, Chen ZW, Caccia S, Cantwell AM, Savvides SN, Waksman G, Mathews FS, Di Cera E, J Biol Chem. 2004 Sep 17;279(38):39824-8. Epub 2004 Jul 13. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15252033 15252033]
The anticoagulant thrombin mutant W215A/E217A has a collapsed primary specificity pocket., Pineda AO, Chen ZW, Caccia S, Cantwell AM, Savvides SN, Waksman G, Mathews FS, Di Cera E, J Biol Chem. 2004 Sep 17;279(38):39824-8. Epub 2004 Jul 13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15252033 15252033]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: thrombin]]
[[Category: thrombin]]


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