1tsn: Difference between revisions

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[[Image:1tsn.jpg|left|200px]]<br /><applet load="1tsn" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1tsn.jpg|left|200px]]
caption="1tsn, resolution 2.2&Aring;" />
 
'''THYMIDYLATE SYNTHASE TERNARY COMPLEX WITH FDUMP AND METHYLENETETRAHYDROFOLATE'''<br />
{{Structure
|PDB= 1tsn |SIZE=350|CAPTION= <scene name='initialview01'>1tsn</scene>, resolution 2.2&Aring;
|SITE= <scene name='pdbsite=S1:Carboxy+Modification+At+N1'>S1</scene>
|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=UFP:5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE'>UFP</scene> and <scene name='pdbligand=C2F:5-METHYL-5,6,7,8-TETRAHYDROFOLIC ACID'>C2F</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45]
|GENE=
}}
 
'''THYMIDYLATE SYNTHASE TERNARY COMPLEX WITH FDUMP AND METHYLENETETRAHYDROFOLATE'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1TSN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=PO4:'>PO4</scene>, <scene name='pdbligand=UFP:'>UFP</scene> and <scene name='pdbligand=C2F:'>C2F</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] Known structural/functional Site: <scene name='pdbsite=S1:Carboxy+Modification+At+N1'>S1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TSN OCA].  
1TSN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TSN OCA].  


==Reference==
==Reference==
Use of strain in a stereospecific catalytic mechanism: crystal structures of Escherichia coli thymidylate synthase bound to FdUMP and methylenetetrahydrofolate., Hyatt DC, Maley F, Montfort WR, Biochemistry. 1997 Apr 15;36(15):4585-94. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9109668 9109668]
Use of strain in a stereospecific catalytic mechanism: crystal structures of Escherichia coli thymidylate synthase bound to FdUMP and methylenetetrahydrofolate., Hyatt DC, Maley F, Montfort WR, Biochemistry. 1997 Apr 15;36(15):4585-94. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9109668 9109668]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: transferase]]
[[Category: transferase]]


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