1svf

PARAMYXOVIRUS SV5 FUSION PROTEIN CORE

spinqualitylabelsall models 1svf, resolution 1.40Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1svf is a 4 chain structure with sequence from Simian virus 5 (strain w3). Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: CL Gene: FUSION PROTEIN (Simian virus 5 (strain W3)) Resources: FirstGlance, OCA, RCSB, PDBsum Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed Paramyxoviruses are responsible for significant human mortality and disease worldwide, but the molecular mechanisms underlying their entry into host cells remain poorly understood. We have solved the crystal structure of a fragment of the simian parainfluenza virus 5 fusion protein (SV5 F), revealing a 96 A long coiled coil surrounded by three antiparallel helices. This structure places the fusion and transmembrane anchor of SV5 F in close proximity with a large intervening domain at the opposite end of the coiled coil. Six amino acids, potentially part of the fusion peptide, form a segment of the central coiled coil, suggesting that this structure extends into the membrane. Deletion mutants of SV5 F indicate that putative flexible tethers between the coiled coil and the viral membrane are dispensable for fusion. The lack of flexible tethers may couple a final conformational change in the F protein directly to the fusion of two bilayers. Structural basis for paramyxovirus-mediated membrane fusion.,Baker KA, Dutch RE, Lamb RA, Jardetzky TS Mol Cell. 1999 Mar;3(3):309-19. PMID:10198633 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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