1txd: Difference between revisions
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{{STRUCTURE_1txd| PDB=1txd | SCENE= }} | {{STRUCTURE_1txd| PDB=1txd | SCENE= }} | ||
===Crystal Structure of the DH/PH domains of Leukemia-associated RhoGEF=== | |||
{{ABSTRACT_PUBMED_15331592}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/ARHGC_HUMAN ARHGC_HUMAN]] Note=A chromosomal aberration involving ARHGEF12 may be a cause of acute leukemia. Translocation t(11;11)(q23;23) with MLL. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/ARHGC_HUMAN ARHGC_HUMAN]] May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13.<ref>PMID:11094164</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:015331592</ref><references group="xtra"/> | <ref group="xtra">PMID:015331592</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Gao, G.]] | [[Category: Gao, G.]] | ||
Revision as of 05:20, 25 March 2013
Crystal Structure of the DH/PH domains of Leukemia-associated RhoGEF
Template:ABSTRACT PUBMED 15331592
Disease
[ARHGC_HUMAN] Note=A chromosomal aberration involving ARHGEF12 may be a cause of acute leukemia. Translocation t(11;11)(q23;23) with MLL.
Function
[ARHGC_HUMAN] May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13.[1]
About this Structure
1txd is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Kristelly R, Gao G, Tesmer JJ. Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factor. J Biol Chem. 2004 Nov 5;279(45):47352-62. Epub 2004 Aug 25. PMID:15331592 doi:https://dx.doi.org/10.1074/jbc.M406056200
