1umk: Difference between revisions

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~~[[Image:1umk.png|left|200px]]~~

===The Structure of Human Erythrocyte NADH-cytochrome b5 Reductase===

===~~The Structure~~ of ~~Human Erythrocyte NADH~~-~~cytochrome b5 Reductase===~~

==Disease==

[[http://www.uniprot.org/uniprot/NCB5R_HUMAN NCB5R_HUMAN]] Defects in CYB5R3 are the cause of methemoglobinemia CYB5R3-related (METHB-CYB5R3) [MIM:[http://omim.org/entry/250800 250800]]. A form of methemoglobinemia, a hematologic disease characterized by the presence of excessive amounts of methemoglobin in blood cells, resulting in decreased oxygen carrying capacity of the blood, cyanosis and hypoxia. There are two types of methemoglobinemia CYB5R3-related. In type 1, the defect affects the soluble form of the enzyme, is restricted to red blood cells, and causes well-tolerated methemoglobinemia. In type 2, the defect affects both the soluble and microsomal forms of the enzyme and is thus generalized, affecting red cells, leukocytes and all body tissues. Type 2 methemoglobinemia is associated with mental deficiency and other neurologic symptoms.<ref>PMID:1898726</ref><ref>PMID:1707593</ref><ref>PMID:1400360</ref><ref>PMID:8119939</ref><ref>PMID:7718898</ref><ref>PMID:9695975</ref><ref>PMID:9886302</ref><ref>PMID:10807796</ref><ref>PMID:15622768</ref><ref>PMID:12393396</ref><ref>PMID:15953014</ref>

~~{{ABSTRACT_PUBMED_15502298}}~~

==Function==

[[http://www.uniprot.org/uniprot/NCB5R_HUMAN NCB5R_HUMAN]] Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.

==About this Structure==

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==Reference==

[[Category: Cytochrome-b5 reductase]]

[[Category: Homo sapiens]]

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@@ Line 1: / Line 1: @@
-[[Image:1umk.png|left|200px]]
 {{STRUCTURE_1umk|  PDB=1umk  |  SCENE=  }}
+===The Structure of Human Erythrocyte NADH-cytochrome b5 Reductase===
+{{ABSTRACT_PUBMED_15502298}}
-===The Structure of Human Erythrocyte NADH-cytochrome b5 Reductase===
+==Disease==
+[[http://www.uniprot.org/uniprot/NCB5R_HUMAN NCB5R_HUMAN]] Defects in CYB5R3 are the cause of methemoglobinemia CYB5R3-related (METHB-CYB5R3) [MIM:[http://omim.org/entry/250800 250800]]. A form of methemoglobinemia, a hematologic disease characterized by the presence of excessive amounts of methemoglobin in blood cells, resulting in decreased oxygen carrying capacity of the blood, cyanosis and hypoxia. There are two types of methemoglobinemia CYB5R3-related. In type 1, the defect affects the soluble form of the enzyme, is restricted to red blood cells, and causes well-tolerated methemoglobinemia. In type 2, the defect affects both the soluble and microsomal forms of the enzyme and is thus generalized, affecting red cells, leukocytes and all body tissues. Type 2 methemoglobinemia is associated with mental deficiency and other neurologic symptoms.<ref>PMID:1898726</ref><ref>PMID:1707593</ref><ref>PMID:1400360</ref><ref>PMID:8119939</ref><ref>PMID:7718898</ref><ref>PMID:9695975</ref><ref>PMID:9886302</ref><ref>PMID:10807796</ref><ref>PMID:15622768</ref><ref>PMID:12393396</ref><ref>PMID:15953014</ref>
-{{ABSTRACT_PUBMED_15502298}}
+==Function==
+[[http://www.uniprot.org/uniprot/NCB5R_HUMAN NCB5R_HUMAN]] Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.
 ==About this Structure==
@@ Line 11: / Line 13: @@
 ==Reference==
-<ref group="xtra">PMID:015502298</ref><references group="xtra"/>
+<ref group="xtra">PMID:015502298</ref><references group="xtra"/><references/>
 [[Category: Cytochrome-b5 reductase]]
 [[Category: Homo sapiens]]