1x86: Difference between revisions
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{{STRUCTURE_1x86| PDB=1x86 | SCENE= }} | {{STRUCTURE_1x86| PDB=1x86 | SCENE= }} | ||
===Crystal Structure of the DH/PH domains of Leukemia-associated RhoGEF in complex with RhoA=== | |||
{{ABSTRACT_PUBMED_15331592}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/ARHGC_HUMAN ARHGC_HUMAN]] Note=A chromosomal aberration involving ARHGEF12 may be a cause of acute leukemia. Translocation t(11;11)(q23;23) with MLL. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/ARHGC_HUMAN ARHGC_HUMAN]] May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13.<ref>PMID:11094164</ref> [[http://www.uniprot.org/uniprot/RHOA_HUMAN RHOA_HUMAN]] Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.<ref>PMID:8910519</ref><ref>PMID:9121475</ref><ref>PMID:12900402</ref><ref>PMID:16103226</ref><ref>PMID:16236794</ref><ref>PMID:19934221</ref><ref>PMID:20937854</ref><ref>PMID:20974804</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:015331592</ref><references group="xtra"/> | <ref group="xtra">PMID:015331592</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Gao, G.]] | [[Category: Gao, G.]] | ||
