1yk0: Difference between revisions
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{{STRUCTURE_1yk0| PDB=1yk0 | SCENE= }} | {{STRUCTURE_1yk0| PDB=1yk0 | SCENE= }} | ||
===structure of natriuretic peptide receptor-C complexed with atrial natriuretic peptide=== | |||
{{ABSTRACT_PUBMED_16870210}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/ANF_HUMAN ANF_HUMAN]] Defects in NPPA are the cause of familial atrial fibrillation type 6 (ATFB6) [MIM:[http://omim.org/entry/612201 612201]]. Atrial fibrillation is a common disorder of cardiac rhythm that is hereditary in a small subgroup of patients. It is characterized by disorganized atrial electrical activity, progressive deterioration of atrial electromechanical function and ineffective pumping of blood into the ventricles. It can be associated with palpitations, syncope, thromboembolic stroke, and congestive heart failure.<ref>PMID:18614783</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/ANF_HUMAN ANF_HUMAN]] Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.<ref>PMID:1672777</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:016870210</ref><references group="xtra"/> | <ref group="xtra">PMID:016870210</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Garcia, K C.]] | [[Category: Garcia, K C.]] | ||
