1yo4: Difference between revisions

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[[~~Image~~:1yo4.~~png|left|200px~~]]

==Solution Structure of the SARS Coronavirus ORF 7a coded X4 protein==

== Structural highlights ==

<table><tr><td colspan='2'>[[1yo4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YO4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YO4 FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yo4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yo4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yo4 RCSB], [http://www.ebi.ac.uk/pdbsum/1yo4 PDBsum]</span></td></tr>

</table>

== Publication Abstract from PubMed ==

The SARS related Coronavirus genome contains a variety of novel accessory genes. One of these, called ORF7a or ORF8, code for a protein, known as 7a, U122 or X4. We set out to determine the three-dimensional structure of the soluble ectodomain of this type-I transmembrane protein by nuclear magnetic resonance spectroscopy. The fold of the protein is the first member of a further variation of the immunoglobulin like beta-sandwich fold. Because X4 does not reveal significant sequence homologies to proteins in the data bases, we carried out a structure based similarity search for proteins with known function. High structural similarity to Dl domains of ICAM-1 and ICAM-2, and common features in amino acid sequence between X4 and ICAM-1, suggest X4 to possess binding activity for the alpha(L) integrin I domain of LFA-1. Further, based on this structure based prediction, potential functions of X4 in virus replication and pathogenesis are discussed.

~~{{STRUCTURE_1yo4| PDB=1yo4 | SCENE= }}~~

Solution structure of the X4 protein coded by the SARS related coronavirus reveals an immunoglobulin like fold and suggests a binding activity to integrin I domains.,Hanel K, Stangler T, Stoldt M, Willbold D J Biomed Sci. 2006 May;13(3):281-93. Epub 2005 Nov 23. PMID:16328780<ref>PMID:16328780</ref>

~~===Solution Structure~~ of the ~~SARS Coronavirus ORF 7a coded X4 protein===~~

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

</div>

~~{{ABSTRACT_PUBMED_16328780}}~~

== References ==

==~~About this Structure~~==

__TOC__

~~[[1yo4]] is a 1 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YO4 OCA].~~

</StructureSection>

[[Category: Sars coronavirus]]

[[Category: Haenel, K.]]

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@@ Line 1: / Line 1: @@
-[[Image:1yo4.png|left|200px]]
+==Solution Structure of the SARS Coronavirus ORF 7a coded X4 protein==
+<StructureSection load='1yo4' size='340' side='right' caption='[[1yo4]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1yo4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YO4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YO4 FirstGlance]. <br>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yo4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yo4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yo4 RCSB], [http://www.ebi.ac.uk/pdbsum/1yo4 PDBsum]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The SARS related Coronavirus genome contains a variety of novel accessory genes. One of these, called ORF7a or ORF8, code for a protein, known as 7a, U122 or X4. We set out to determine the three-dimensional structure of the soluble ectodomain of this type-I transmembrane protein by nuclear magnetic resonance spectroscopy. The fold of the protein is the first member of a further variation of the immunoglobulin like beta-sandwich fold. Because X4 does not reveal significant sequence homologies to proteins in the data bases, we carried out a structure based similarity search for proteins with known function. High structural similarity to Dl domains of ICAM-1 and ICAM-2, and common features in amino acid sequence between X4 and ICAM-1, suggest X4 to possess binding activity for the alpha(L) integrin I domain of LFA-1. Further, based on this structure based prediction, potential functions of X4 in virus replication and pathogenesis are discussed.
-{{STRUCTURE_1yo4|  PDB=1yo4  |  SCENE=  }}
+Solution structure of the X4 protein coded by the SARS related coronavirus reveals an immunoglobulin like fold and suggests a binding activity to integrin I domains.,Hanel K, Stangler T, Stoldt M, Willbold D J Biomed Sci. 2006 May;13(3):281-93. Epub 2005 Nov 23. PMID:16328780<ref>PMID:16328780</ref>
-===Solution Structure of the SARS Coronavirus ORF 7a coded X4 protein===
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-{{ABSTRACT_PUBMED_16328780}}
+== References ==
+<references/>
-==About this Structure==
+__TOC__
-[[1yo4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YO4 OCA].
+</StructureSection>
 [[Category: Sars coronavirus]]
 [[Category: Haenel, K.]]