Sandbox Reserved 707: Difference between revisions
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These studies indicate that the binding of an inhibitor to C-RAF leads to the formation of a C-RAF homodimer and C-RAF activation resulting in downstream MEK-ERK activation. Another possible, but not mutually exclusive, mechanism is that binding of an inhibitor to B-RAF leads to the formation of a B-RAF–C-RAF heterodimer and C-RAF activation. That RAF-kinase-induced paradoxical activation occurs in B-RAF -/- mouse embryonic fibroblasts does not rule out the possibility that B-RAF–C-RAF heterodimers play a role in paradoxical activation. A recent study showed that A-RAF acts as a Scaffold to stabilize the heterodimers of B-RAF and C-RAF<ref>PMID:22927515</ref>. | These studies indicate that the binding of an inhibitor to C-RAF leads to the formation of a C-RAF homodimer and C-RAF activation resulting in downstream MEK-ERK activation. Another possible, but not mutually exclusive, mechanism is that binding of an inhibitor to B-RAF leads to the formation of a B-RAF–C-RAF heterodimer and C-RAF activation. That RAF-kinase-induced paradoxical activation occurs in B-RAF -/- mouse embryonic fibroblasts does not rule out the possibility that B-RAF–C-RAF heterodimers play a role in paradoxical activation. A recent study showed that A-RAF acts as a Scaffold to stabilize the heterodimers of B-RAF and C-RAF<ref>PMID:22927515</ref>. | ||
<Structure load='3omv' size=' | <Structure load='3omv' size='400' frame='true' align='left' caption='3D View of C-RAF' scene='Insert optional scene name here' /> | ||
== B-RAF in cancers == | == B-RAF in cancers == | ||
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== External Ressources == | == External Ressources == | ||
[http://www.rcsb.org/pdb/explore/explore.do?structureId=1UWH PDB file for 1UWH] | [http://www.rcsb.org/pdb/explore/explore.do?structureId=1UWH PDB file for 1UWH]<Br /> | ||
[http://www.rcsb.org/pdb/explore/explore.do?structureId=3OMV PDB file for 3OMV] | [http://www.rcsb.org/pdb/explore/explore.do?structureId=3OMV PDB file for 3OMV] | ||
