Sandbox Reserved 706: Difference between revisions
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*The first contact area of the Rab27B/Slac2-a interface consists of <scene name='Sandbox_Reserved_706/6a9_rabcdr/1'> residues 6 to 9 from the Rab complementarity-determining regions (RabCDR)</scene> , part of the switch and interswitch regions of Rab27B, and the coiled-coil regions of Slac2-a.<ref>PMID:18940604</ref> In this first contact area we can find three different types of interactions, electrostatic, hydrophobic and hydrogen bonds: (see figure 3A) | *The first contact area of the Rab27B/Slac2-a interface consists of <scene name='Sandbox_Reserved_706/6a9_rabcdr/1'> residues 6 to 9 from the Rab complementarity-determining regions (RabCDR)</scene> , part of the switch and interswitch regions of Rab27B, and the coiled-coil regions of Slac2-a.<ref>PMID:18940604</ref> In this first contact area we can find three different types of interactions, electrostatic, hydrophobic and hydrogen bonds: (see figure 3A) | ||
-Phe81, Leu84, and Phe88 from switch 2 of Rab27B participate in hydrophobic interactions with the residues from α1 and α5 of Slac2-a. | -<scene name='Sandbox_Reserved_706/Phe81_leu84_phe88/1'>Phe81, Leu84, and Phe88</scene> from switch 2 of Rab27B participate in hydrophobic interactions with the residues from α1 and α5 of Slac2-a. | ||
Furthermore, Trp73 of Rab27B is located in the middle of this contact area, and it plays a central role in the hydrophobic interactions but also for Slac2-a binding. .<ref>PMID:18940604</ref> | Furthermore, Trp73 of Rab27B is located in the middle of this contact area, and it plays a central role in the hydrophobic interactions but also for Slac2-a binding. .<ref>PMID:18940604</ref> | ||
