Sandbox Reserved 706: Difference between revisions
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There are three contact areas in the interface between Rab27B and Slac2-a. The first and second contact areas involve the coiled-coil regions of Slac2-a and constitute the main interface. | There are three contact areas in the interface between Rab27B and Slac2-a. The first and second contact areas involve the coiled-coil regions of Slac2-a and constitute the main interface. | ||
*The first contact area of the Rab27B/Slac2-a interface consists of <scene name='Sandbox_Reserved_706/6a9_rabcdr/ | *The first contact area of the Rab27B/Slac2-a interface consists of <scene name='Sandbox_Reserved_706/6a9_rabcdr/2'> residues 6 to 9 from the Rab complementarity-determining regions (RabCDR)</scene> , part of the switch and interswitch regions of Rab27B, and the coiled-coil regions of Slac2-a.<ref>PMID:18940604</ref> In this first contact area we can find three different types of interactions, electrostatic, hydrophobic and hydrogen bonds: (see figure 3A) | ||
-<scene name='Sandbox_Reserved_706/Phe81_leu84_phe88/1'>Phe81, Leu84, and Phe88</scene> from <scene name='Sandbox_Reserved_706/Switch2_rab27b/1'>switch 2</scene> of Rab27B participate in hydrophobic interactions with the residues from <scene name='Sandbox_Reserved_706/Alpha_5_et_1_de_slac2/1'>α1 and α5</scene> of Slac2-a. | -<scene name='Sandbox_Reserved_706/Phe81_leu84_phe88/1'>Phe81, Leu84, and Phe88</scene> from <scene name='Sandbox_Reserved_706/Switch2_rab27b/1'>switch 2</scene> of Rab27B participate in hydrophobic interactions with the residues from <scene name='Sandbox_Reserved_706/Alpha_5_et_1_de_slac2/1'>α1 and α5</scene> of Slac2-a. | ||
