2dxs: Difference between revisions

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Revision as of 09:40, 6 January 2013

File:2dxs.png

Template:STRUCTURE 2dxs

Crystal structure of HCV NS5B RNA polymerase complexed with a tetracyclic inhibitor

Template:ABSTRACT PUBMED 17125247

About this Structure

2dxs is a 2 chain structure with sequence from Hepatitis c virus. Full crystallographic information is available from OCA.

Reference

  1. Ikegashira K, Oka T, Hirashima S, Noji S, Yamanaka H, Hara Y, Adachi T, Tsuruha J, Doi S, Hase Y, Noguchi T, Ando I, Ogura N, Ikeda S, Hashimoto H. Discovery of conformationally constrained tetracyclic compounds as potent hepatitis C virus NS5B RNA polymerase inhibitors. J Med Chem. 2006 Nov 30;49(24):6950-3. PMID:17125247 doi:10.1021/jm0610245

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