1uwj: Difference between revisions

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[[Image:1uwj.jpg|left|200px]]<br /><applet load="1uwj" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1uwj.jpg|left|200px]]
caption="1uwj, resolution 3.50&Aring;" />
 
'''THE COMPLEX OF MUTANT V599E B-RAF AND BAY439006'''<br />
{{Structure
|PDB= 1uwj |SIZE=350|CAPTION= <scene name='initialview01'>1uwj</scene>, resolution 3.50&Aring;
|SITE= <scene name='pdbsite=AC1:Bax+Binding+Site+For+Chain+B'>AC1</scene>
|LIGAND= <scene name='pdbligand=BAX:4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE'>BAX</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Transferred_entry:_2.7.11.1 Transferred entry: 2.7.11.1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.37 2.7.1.37]
|GENE=
}}
 
'''THE COMPLEX OF MUTANT V599E B-RAF AND BAY439006'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1UWJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=BAX:'>BAX</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Transferred_entry:_2.7.11.1 Transferred entry: 2.7.11.1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.37 2.7.1.37] Known structural/functional Site: <scene name='pdbsite=AC1:Bax+Binding+Site+For+Chain+B'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UWJ OCA].  
1UWJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UWJ OCA].  


==Reference==
==Reference==
Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF., Wan PT, Garnett MJ, Roe SM, Lee S, Niculescu-Duvaz D, Good VM, Jones CM, Marshall CJ, Springer CJ, Barford D, Marais R, Cell. 2004 Mar 19;116(6):855-67. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15035987 15035987]
Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF., Wan PT, Garnett MJ, Roe SM, Lee S, Niculescu-Duvaz D, Good VM, Jones CM, Marshall CJ, Springer CJ, Barford D, Marais R, Cell. 2004 Mar 19;116(6):855-67. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15035987 15035987]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: threonine-protein kinase]]
[[Category: threonine-protein kinase]]


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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:37:45 2008''
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