2c80: Difference between revisions
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{{STRUCTURE_2c80| PDB=2c80 | SCENE= }} | {{STRUCTURE_2c80| PDB=2c80 | SCENE= }} | ||
===Structure of Sh28GST in complex with S-hexyl Glutathione=== | |||
{{ABSTRACT_PUBMED_16777141}} | |||
=== | ==Function== | ||
[[http://www.uniprot.org/uniprot/GST28_SCHBO GST28_SCHBO]] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut. | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:016777141</ref><references group="xtra"/> | <ref group="xtra">PMID:016777141</ref><references group="xtra"/><references/> | ||
[[Category: Glutathione transferase]] | [[Category: Glutathione transferase]] | ||
[[Category: Schistosoma haematobium]] | [[Category: Schistosoma haematobium]] | ||
Revision as of 06:52, 8 May 2013
Structure of Sh28GST in complex with S-hexyl Glutathione
Template:ABSTRACT PUBMED 16777141
Function
[GST28_SCHBO] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut.
About this Structure
2c80 is a 2 chain structure with sequence from Schistosoma haematobium. Full crystallographic information is available from OCA.
See Also
Reference
- Baiocco P, Gourlay LJ, Angelucci F, Fontaine J, Herve M, Miele AE, Trottein F, Brunori M, Bellelli A. Probing the mechanism of GSH activation in Schistosoma haematobium glutathione-S-transferase by site-directed mutagenesis and X-ray crystallography. J Mol Biol. 2006 Jul 14;360(3):678-89. Epub 2006 Jun 2. PMID:16777141 doi:10.1016/j.jmb.2006.05.040
