2a3w: Difference between revisions
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{{STRUCTURE_2a3w| PDB=2a3w | SCENE= }} | {{STRUCTURE_2a3w| PDB=2a3w | SCENE= }} | ||
===Decameric structure of human serum amyloid P-component bound to Bis-1,2-{[(Z)-2-carboxy-2-methyl-1,3-dioxane]-5-yloxycarbamoyl}-ethane=== | |||
{{ABSTRACT_PUBMED_16036920}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/SAMP_HUMAN SAMP_HUMAN]] Note=SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/SAMP_HUMAN SAMP_HUMAN]] Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin. | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:016036920</ref><references group="xtra"/> | <ref group="xtra">PMID:016036920</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Bundle, D R.]] | [[Category: Bundle, D R.]] | ||
Revision as of 19:41, 24 March 2013
Decameric structure of human serum amyloid P-component bound to Bis-1,2-{[(Z)-2-carboxy-2-methyl-1,3-dioxane]-5-yloxycarbamoyl}-ethane
Template:ABSTRACT PUBMED 16036920
Disease
[SAMP_HUMAN] Note=SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits.
Function
[SAMP_HUMAN] Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin.
About this Structure
2a3w is a 20 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Ho JG, Kitov PI, Paszkiewicz E, Sadowska J, Bundle DR, Ng KK. Ligand-assisted aggregation of proteins. Dimerization of serum amyloid P component by bivalent ligands. J Biol Chem. 2005 Sep 9;280(36):31999-2008. Epub 2005 Jul 20. PMID:16036920 doi:10.1074/jbc.M504403200
