2cov: Difference between revisions
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[[ | ==Crystal structure of CBM31 from beta-1,3-xylanase== | ||
<StructureSection load='2cov' size='340' side='right' caption='[[2cov]], [[Resolution|resolution]] 1.25Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2cov]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Alcaligenes_sp. Alcaligenes sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2COV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2COV FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cov OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cov RCSB], [http://www.ebi.ac.uk/pdbsum/2cov PDBsum]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/Q8RS40_9BURK Q8RS40_9BURK]] Catalyzes the hydrolysis of beta-1,3-xylan into oligosaccharides, mainly xylotriose and xylobiose with smaller amounts of xylotetraose, xylose, xylopentaose and xylohexaose. Does not hydrolyze xylobiose, p-nitrophenyl-beta-xyloside, beta-1,4-xylan, carboxymethylcellulose, curdlan, glucomannan or beta-1,4-mannan.<ref>PMID:11948152</ref> <ref>PMID:12501421</ref> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Here, we present the crystal structure of the family 31 carbohydrate-binding module (CBM) of beta-1,3-xylanase from Alcaligenes sp. strain XY-234 (AlcCBM31) determined at a resolution of 1.25A. The AlcCBM31 shows affinity with only beta-1,3-xylan. The AlcCBM31 molecule makes a beta-sandwich structure composed of eight beta-strands with a typical immunoglobulin fold and contains two intra-molecular disulfide bonds. The folding topology of AlcCBM31 differs from that of the large majority of other CBMs, in which eight beta-strands comprise a beta-sandwich structure with a typical jelly-roll fold. AlcCBM31 shows structural similarity with CBM structures of family 34 and family 9, which also adopt structures based on immunoglobulin folds. | |||
The first crystal structure of a family 31 carbohydrate-binding module with affinity to beta-1,3-xylan.,Hashimoto H, Tamai Y, Okazaki F, Tamaru Y, Shimizu T, Araki T, Sato M FEBS Lett. 2005 Aug 15;579(20):4324-8. PMID:16061225<ref>PMID:16061225</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== References == | |||
<references/> | |||
== | __TOC__ | ||
</StructureSection> | |||
[[Category: Alcaligenes sp | [[Category: Alcaligenes sp]] | ||
[[Category: Araki, T | [[Category: Araki, T]] | ||
[[Category: Hashimoto, H | [[Category: Hashimoto, H]] | ||
[[Category: Okazaki, F | [[Category: Okazaki, F]] | ||
[[Category: Sato, M | [[Category: Sato, M]] | ||
[[Category: Shimizu, T | [[Category: Shimizu, T]] | ||
[[Category: Tamai, Y | [[Category: Tamai, Y]] | ||
[[Category: Tamaru, Y | [[Category: Tamaru, Y]] | ||
[[Category: 3-xylanase]] | [[Category: 3-xylanase]] | ||
[[Category: Beta-1]] | [[Category: Beta-1]] | ||
