2csa: Difference between revisions
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{{STRUCTURE_2csa| PDB=2csa | SCENE= }} | {{STRUCTURE_2csa| PDB=2csa | SCENE= }} | ||
===Structure of the M3 Muscarinic Acetylcholine Receptor Basolateral Sorting Signal=== | |||
{{ABSTRACT_PUBMED_15870063}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/ACM3_HUMAN ACM3_HUMAN]] Defects in CHRM3 are the cause of Eagle-Barrett syndrome (EGBRS) [MIM:[http://omim.org/entry/100100 100100]]. EGBRS is a syndrome characterized by thin abdominal musculature with overlying lax skin, cryptorchism, megacystis with disorganized detrusor muscle, and urinary tract abnormalities.<ref>PMID:22077972</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/ACM3_HUMAN ACM3_HUMAN]] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. | |||
==About this Structure== | ==About this Structure== | ||
[[2csa]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSA OCA]. | [[2csa]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSA OCA]. | ||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Fox, D.]] | [[Category: Fox, D.]] | ||
[[Category: Iverson, H A.]] | [[Category: Iverson, H A.]] | ||
