2dmo: Difference between revisions
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{{STRUCTURE_2dmo| PDB=2dmo | SCENE= }} | {{STRUCTURE_2dmo| PDB=2dmo | SCENE= }} | ||
===Refined solution structure of the 1st SH3 domain from human Neutrophil cytosol factor 2 (NCF-2)=== | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/NCF2_HUMAN NCF2_HUMAN]] Defects in NCF2 are a cause of chronic granulomatous disease autosomal recessive cytochrome-b-positive type 2 (CGD2) [MIM:[http://omim.org/entry/233710 233710]]. Chronic granulomatous disease is a genetically heterogeneous disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections.<ref>PMID:8286749</ref><ref>PMID:9070911</ref><ref>PMID:10498624</ref><ref>PMID:10598813</ref><ref>PMID:11112388</ref><ref>PMID:16937026</ref><ref>PMID:18625437</ref><ref>PMID:19624736</ref><ref>PMID:20167518</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/NCF2_HUMAN NCF2_HUMAN]] NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production). | |||
==About this Structure== | ==About this Structure== | ||
[[2dmo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1x3v 1x3v]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DMO OCA]. | [[2dmo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1x3v 1x3v]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DMO OCA]. | ||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Chikayama, E.]] | [[Category: Chikayama, E.]] | ||
