1gu2: Difference between revisions
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==Overview== | ==Overview== | ||
The crystal structures of the oxidized and reduced forms of cytochrome c", from Methylophilus methylotrophus were solved from X-ray synchrotron data, to atomic resolution. The overall fold of the molecule in the two redox, states is very similar and is comparable to that of the oxygen-binding, protein from the purple phototrophic bacterium Rhodobacter sphaeroides., However, significant modifications occur near the haem group, in, particular the detachment from axial binding of His95 observed upon, reduction as well as the adoption of different conformations of some, protonatable residues that form a possible proton path from the haem, pocket to the protein surface. These changes are associated with the, previously well characterized redox-Bohr behaviour of this protein., Furthermore they . | The crystal structures of the oxidized and reduced forms of cytochrome c", from Methylophilus methylotrophus were solved from X-ray synchrotron data, to atomic resolution. The overall fold of the molecule in the two redox, states is very similar and is comparable to that of the oxygen-binding, protein from the purple phototrophic bacterium Rhodobacter sphaeroides., However, significant modifications occur near the haem group, in, particular the detachment from axial binding of His95 observed upon, reduction as well as the adoption of different conformations of some, protonatable residues that form a possible proton path from the haem, pocket to the protein surface. These changes are associated with the, previously well characterized redox-Bohr behaviour of this protein., Furthermore they provide a model for one of the presently proposed, mechanisms of proton translocation in the much more complex protein, cytochrome c oxidase. | ||
==About this Structure== | ==About this Structure== | ||
1GU2 is a | 1GU2 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Methylophilus_methylotrophus Methylophilus methylotrophus] with HEC as [http://en.wikipedia.org/wiki/ligand ligand]. Structure known Active Site: HEA. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GU2 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: oxidoreductase]] | [[Category: oxidoreductase]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 13:07:04 2007'' | ||
