1gv4: Difference between revisions
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==Overview== | ==Overview== | ||
Mitochondria play a key role in apoptosis due to their capacity to release, potentially lethal proteins. One of these latent death factors is, cytochrome c, which can stimulate the proteolytic activation of caspase, zymogens. Another important protein is apoptosis-inducing factor (AIF), a, flavoprotein that can stimulate a caspase-independent cell-death pathway, required for early embryonic morphogenesis. Here, we report the crystal, structure of mouse AIF at 2.0 A. Its active site structure and redox, properties suggest that AIF functions as an electron transferase with a, mechanism similar to that of the bacterial ferredoxin reductases, its, closest evolutionary homologs. However, AIF structurally differs from, these proteins in some essential features, including a long insertion in a, . | Mitochondria play a key role in apoptosis due to their capacity to release, potentially lethal proteins. One of these latent death factors is, cytochrome c, which can stimulate the proteolytic activation of caspase, zymogens. Another important protein is apoptosis-inducing factor (AIF), a, flavoprotein that can stimulate a caspase-independent cell-death pathway, required for early embryonic morphogenesis. Here, we report the crystal, structure of mouse AIF at 2.0 A. Its active site structure and redox, properties suggest that AIF functions as an electron transferase with a, mechanism similar to that of the bacterial ferredoxin reductases, its, closest evolutionary homologs. However, AIF structurally differs from, these proteins in some essential features, including a long insertion in a, C-terminal beta-hairpin loop, which may be related to its apoptogenic, functions. | ||
==About this Structure== | ==About this Structure== | ||
1GV4 is a | 1GV4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with FAD as [http://en.wikipedia.org/wiki/ligand ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GV4 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: oxidoreductase]] | [[Category: oxidoreductase]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 14:44:30 2007'' | ||
