1vhr: Difference between revisions

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[[Image:1vhr.gif|left|200px]]<br /><applet load="1vhr" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1vhr.gif|left|200px]]
caption="1vhr, resolution 2.1&Aring;" />
 
'''HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE'''<br />
{{Structure
|PDB= 1vhr |SIZE=350|CAPTION= <scene name='initialview01'>1vhr</scene>, resolution 2.1&Aring;
|SITE= <scene name='pdbsite=GAA:The+Loop+Containing+The+Putative+General+Acid+ASP+92'>GAA</scene>, <scene name='pdbsite=GAB:The+Loop+Containing+The+Putative+General+Acid+ASP+92'>GAB</scene>, <scene name='pdbsite=PLA:Phosphate+Binding+Loop+Including+Catalytic+Nucleophile+C+...'>PLA</scene>, <scene name='pdbsite=PLB:Phosphate+Binding+Loop+Including+Catalytic+Nucleophile+C+...'>PLB</scene>, <scene name='pdbsite=RCA:Designated+Recognition+Region+In+Primary+Reference.+Prop+...'>RCA</scene>, <scene name='pdbsite=RCB:Designated+Recognition+Region+In+Primary+Reference.+Prop+...'>RCB</scene>, <scene name='pdbsite=VRA:The+Region+Containing+High+Variation+Among+The+Dual-Spec+...'>VRA</scene> and <scene name='pdbsite=VRB:The+Region+Containing+High+Variation+Among+The+Dual-Spec+...'>VRB</scene>
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID'>EPE</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48]
|GENE=
}}
 
'''HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1VHR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=EPE:'>EPE</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] Known structural/functional Sites: <scene name='pdbsite=GAA:The+Loop+Containing+The+Putative+General+Acid+ASP+92'>GAA</scene>, <scene name='pdbsite=GAB:The+Loop+Containing+The+Putative+General+Acid+ASP+92'>GAB</scene>, <scene name='pdbsite=PLA:Phosphate+Binding+Loop+Including+Catalytic+Nucleophile+C+...'>PLA</scene>, <scene name='pdbsite=PLB:Phosphate+Binding+Loop+Including+Catalytic+Nucleophile+C+...'>PLB</scene>, <scene name='pdbsite=RCA:Designated+Recognition+Region+In+Primary+Reference.+Prop+...'>RCA</scene>, <scene name='pdbsite=RCB:Designated+Recognition+Region+In+Primary+Reference.+Prop+...'>RCB</scene>, <scene name='pdbsite=VRA:The+Region+Containing+High+Variation+Among+The+Dual-Spec+...'>VRA</scene> and <scene name='pdbsite=VRB:The+Region+Containing+High+Variation+Among+The+Dual-Spec+...'>VRB</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VHR OCA].  
1VHR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VHR OCA].  


==Reference==
==Reference==
Crystal structure of the dual specificity protein phosphatase VHR., Yuvaniyama J, Denu JM, Dixon JE, Saper MA, Science. 1996 May 31;272(5266):1328-31. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8650541 8650541]
Crystal structure of the dual specificity protein phosphatase VHR., Yuvaniyama J, Denu JM, Dixon JE, Saper MA, Science. 1996 May 31;272(5266):1328-31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8650541 8650541]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein-tyrosine-phosphatase]]
[[Category: Protein-tyrosine-phosphatase]]
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[[Category: protein dual-specificity phosphatase]]
[[Category: protein dual-specificity phosphatase]]


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