2da6: Difference between revisions

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~~[[Image:2da6.png|left|200px]]~~

===Solution structure of the homeobox domain of Hepatocyte nuclear factor 1-beta (HNF-1beta)===

===~~Solution structure~~ of the ~~homeobox domain~~ of ~~Hepatocyte nuclear~~ factor 1-~~beta~~ (~~HNF~~-~~1beta)===~~

==Disease==

[[http://www.uniprot.org/uniprot/HNF1B_HUMAN HNF1B_HUMAN]] Defects in HNF1B are the cause of renal cysts and diabetes syndrome (RCAD) [MIM:[http://omim.org/entry/137920 137920]]; also called maturity-onset diabetes of the young type 5 (MODY5) or familial hypoplastic glomerulocystic kidney disease (GCKD). RCAD is an autosomal dominant disorder comprising non-diabetic renal disease resulting from abnormal renal development, and diabetes, which in some cases occurs earlier than age 25 years and is thus consistent with a diagnosis of maturity-onset diabetes of the young (MODY5). The renal disease is highly variable and includes renal cysts, glomerular tufts, aberrant nephrogenesis, primitive tubules, irregular collecting systems, oligomeganephronia, enlarged renal pelves, abnormal calyces, small kidney, single kidney, horseshoe kidney, and hyperuricemic nephropathy.<ref>PMID:10484768</ref><ref>PMID:10672455</ref><ref>PMID:11845238</ref><ref>PMID:11918730</ref><ref>PMID:14583183</ref><ref>PMID:15068978</ref><ref>PMID:15001636</ref><ref>PMID:15181075</ref><ref>PMID:16249435</ref><ref>PMID:15930087</ref> Defects in HNF1B may be rare genetic risk factor contributing to the development of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:[http://omim.org/entry/125853 125853]]. NIDDM is characterized by an autosomal dominant mode of inheritance, onset during adulthood and insulin resistance.<ref>PMID:12161522</ref> Defects in HNF1B may be a cause of susceptibility to prostate cancer hereditary type 11 (HPC11) [MIM:[http://omim.org/entry/611955 611955]]. It is a condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.

==Function==

[[http://www.uniprot.org/uniprot/HNF1B_HUMAN HNF1B_HUMAN]] Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3'.

==About this Structure==

[[2da6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DA6 OCA].

==Reference==

[[Category: Homo sapiens]]

[[Category: Inoue, M.]]

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@@ Line 1: / Line 1: @@
-[[Image:2da6.png|left|200px]]
 {{STRUCTURE_2da6|  PDB=2da6  |  SCENE=  }}
+===Solution structure of the homeobox domain of Hepatocyte nuclear factor 1-beta (HNF-1beta)===
-===Solution structure of the homeobox domain of Hepatocyte nuclear factor 1-beta (HNF-1beta)===
+==Disease==
+[[http://www.uniprot.org/uniprot/HNF1B_HUMAN HNF1B_HUMAN]] Defects in HNF1B are the cause of renal cysts and diabetes syndrome (RCAD) [MIM:[http://omim.org/entry/137920 137920]]; also called maturity-onset diabetes of the young type 5 (MODY5) or familial hypoplastic glomerulocystic kidney disease (GCKD). RCAD is an autosomal dominant disorder comprising non-diabetic renal disease resulting from abnormal renal development, and diabetes, which in some cases occurs earlier than age 25 years and is thus consistent with a diagnosis of maturity-onset diabetes of the young (MODY5). The renal disease is highly variable and includes renal cysts, glomerular tufts, aberrant nephrogenesis, primitive tubules, irregular collecting systems, oligomeganephronia, enlarged renal pelves, abnormal calyces, small kidney, single kidney, horseshoe kidney, and hyperuricemic nephropathy.<ref>PMID:10484768</ref><ref>PMID:10672455</ref><ref>PMID:11845238</ref><ref>PMID:11918730</ref><ref>PMID:14583183</ref><ref>PMID:15068978</ref><ref>PMID:15001636</ref><ref>PMID:15181075</ref><ref>PMID:16249435</ref><ref>PMID:15930087</ref>  Defects in HNF1B may be rare genetic risk factor contributing to the development of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:[http://omim.org/entry/125853 125853]]. NIDDM is characterized by an autosomal dominant mode of inheritance, onset during adulthood and insulin resistance.<ref>PMID:12161522</ref>  Defects in HNF1B may be a cause of susceptibility to prostate cancer hereditary type 11 (HPC11) [MIM:[http://omim.org/entry/611955 611955]]. It is a condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.
+==Function==
+[[http://www.uniprot.org/uniprot/HNF1B_HUMAN HNF1B_HUMAN]] Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3'.
 ==About this Structure==
 [[2da6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DA6 OCA].
+==Reference==
+<references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Inoue, M.]]