Sandbox Reserved 706: Difference between revisions
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=== '''Structure of Rab27B''' === | === '''Structure of Rab27B''' === | ||
[[Image:Rab27B slac2a | [[Image:Rab27B slac2a image2.jpg | 500 px | thumb | right |Picture 2: Caption: ]] | ||
'''General informations:''' | '''General informations:''' | ||
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<scene name='Sandbox_Reserved_706/Loop_entre_beta_2_et_3/1'>ß2 and ß3 loop (residues 55-64)</scene> and <scene name='Sandbox_Reserved_706/Rab27b_loop_2_alpha3_b5/1'>α3-ß5 loop (residues122-126)</scene> of Rab27B are both regions involved in Slac2-a binding. <ref>PMID:18940604</ref> | <scene name='Sandbox_Reserved_706/Loop_entre_beta_2_et_3/1'>ß2 and ß3 loop (residues 55-64)</scene> and <scene name='Sandbox_Reserved_706/Rab27b_loop_2_alpha3_b5/1'>α3-ß5 loop (residues122-126)</scene> of Rab27B are both regions involved in Slac2-a binding. <ref>PMID:18940604</ref> | ||
[[Image:Rab27B slac2a | [[Image:Rab27B slac2a image1.jpg | 425 px | thumb | left |Picture 1: Caption: ]] | ||
The complex Rab27B/Slac2-a can only be formed when Rab27B is in a GTP form. This can be explained because of the changing of shape between Rab27B in the GTP and GDP form. (See figure 3) | The complex Rab27B/Slac2-a can only be formed when Rab27B is in a GTP form. This can be explained because of the changing of shape between Rab27B in the GTP and GDP form. (See figure 3) | ||
Rab27B–GTP adopts a compact monomer conformation, while an extended conformation was observed for GDP-bound Rab27B. | Rab27B–GTP adopts a compact monomer conformation, while an extended conformation was observed for GDP-bound Rab27B. | ||
