2kdr: Difference between revisions
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[[ | ==Solution structure of HCV NS4B(227-254)== | ||
<StructureSection load='2kdr' size='340' side='right' caption='[[2kdr]], [[NMR_Ensembles_of_Models | 27 NMR models]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2kdr]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KDR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KDR FirstGlance]. <br> | |||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2jxf|2jxf]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kdr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kdr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kdr RCSB], [http://www.ebi.ac.uk/pdbsum/2kdr PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Nonstructural protein 4B (NS4B) plays an essential role in the formation of the hepatitis C virus (HCV) replication complex. It is an integral membrane protein that has been only poorly characterized to date. It is believed to comprise a cytosolic N-terminal part, a central part harboring four transmembrane passages, and a cytosolic C-terminal part. Here, we describe an amphipathic alpha-helix at the C terminus of NS4B (amino acid residues 229 to 253) that mediates membrane association and is involved in the formation of a functional HCV replication complex. | |||
An amphipathic alpha-helix at the C terminus of hepatitis C virus nonstructural protein 4B mediates membrane association.,Gouttenoire J, Montserret R, Kennel A, Penin F, Moradpour D J Virol. 2009 Nov;83(21):11378-84. Epub 2009 Aug 19. PMID:19692468<ref>PMID:19692468</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
== | |||
< | |||
[[Category: Montserret, R.]] | [[Category: Montserret, R.]] | ||
[[Category: Penin, F.]] | [[Category: Penin, F.]] | ||
Revision as of 15:36, 12 October 2014
Solution structure of HCV NS4B(227-254)
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