2i50: Difference between revisions
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{{STRUCTURE_2i50| PDB=2i50 | SCENE= }} | {{STRUCTURE_2i50| PDB=2i50 | SCENE= }} | ||
===Solution Structure of Ubp-M Znf-UBP domain=== | |||
{{ABSTRACT_PUBMED_17512543}} | |||
== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/UBP16_HUMAN UBP16_HUMAN]] Note=A chromosomal aberration involving USP16 is a cause of Chronic myelomonocytic leukemia. Inversion inv(21) (q21;q22) with RUNX1/AML1. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/UBP16_HUMAN UBP16_HUMAN]] Specifically deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-10' of histone H3, and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.<ref>PMID:10077596</ref><ref>PMID:11753566</ref><ref>PMID:17914355</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:017512543</ref><references group="xtra"/> | <ref group="xtra">PMID:017512543</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Ubiquitin thiolesterase]] | [[Category: Ubiquitin thiolesterase]] | ||
