1vsc: Difference between revisions
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'''VCAM-1''' | {{Structure | ||
|PDB= 1vsc |SIZE=350|CAPTION= <scene name='initialview01'>1vsc</scene>, resolution 1.9Å | |||
|SITE= | |||
|LIGAND= | |||
|ACTIVITY= | |||
|GENE= VCAM-D1D2-IG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |||
}} | |||
'''VCAM-1''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1VSC is a [ | 1VSC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VSC OCA]. | ||
==Reference== | ==Reference== | ||
The crystal structure of an N-terminal two-domain fragment of vascular cell adhesion molecule 1 (VCAM-1): a cyclic peptide based on the domain 1 C-D loop can inhibit VCAM-1-alpha 4 integrin interaction., Wang JH, Pepinsky RB, Stehle T, Liu JH, Karpusas M, Browning B, Osborn L, Proc Natl Acad Sci U S A. 1995 Jun 6;92(12):5714-8. PMID:[http:// | The crystal structure of an N-terminal two-domain fragment of vascular cell adhesion molecule 1 (VCAM-1): a cyclic peptide based on the domain 1 C-D loop can inhibit VCAM-1-alpha 4 integrin interaction., Wang JH, Pepinsky RB, Stehle T, Liu JH, Karpusas M, Browning B, Osborn L, Proc Natl Acad Sci U S A. 1995 Jun 6;92(12):5714-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7539925 7539925] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: immunoglobulin fold]] | [[Category: immunoglobulin fold]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:49:04 2008'' | ||
Revision as of 12:49, 20 March 2008
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| 1vsc, resolution 1.9Å | |||||||||||||
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| Gene: | VCAM-D1D2-IG (Homo sapiens) | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
VCAM-1
Overview
Vascular cell adhesion molecule 1 (VCAM-1) represents a structurally and functionally distinct class of immunoglobulin superfamily molecules that bind leukocyte integrins and are involved in inflammatory and immune functions. X-ray crystallography defines the three-dimensional structure of the N-terminal two-domain fragment that participates in ligand binding. Residues in domain 1 important for ligand binding reside in the C-D loop, which projects markedly from one face of the molecule near the contact between domains 1 and 2. A cyclic peptide that mimics this loop inhibits binding of alpha 4 beta 1 integrin-bearing cells to VCAM-1. These data demonstrate how crystallographic structural information can be used to design a small molecule inhibitor of biological function.
Disease
Known diseases associated with this structure: CRASH syndrome OMIM:[308840], Corpus callosum, partial agenesis of OMIM:[308840], Hydrocephalus due to aqueductal stenosis OMIM:[308840], Hydrocephalus with Hirschsprung disease and cleft palate OMIM:[308840], Hydrocephalus with congenital idiopathic intestinal pseudoobstruction OMIM:[308840], MASA syndrome OMIM:[308840]
About this Structure
1VSC is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The crystal structure of an N-terminal two-domain fragment of vascular cell adhesion molecule 1 (VCAM-1): a cyclic peptide based on the domain 1 C-D loop can inhibit VCAM-1-alpha 4 integrin interaction., Wang JH, Pepinsky RB, Stehle T, Liu JH, Karpusas M, Browning B, Osborn L, Proc Natl Acad Sci U S A. 1995 Jun 6;92(12):5714-8. PMID:7539925
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