2ode: Difference between revisions

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~~[[Image:2ode.png|left|200px]]~~

===Crystal structure of the heterodimeric complex of human RGS8 and activated Gi alpha 3===

===~~Crystal structure~~ of the ~~heterodimeric complex~~ of ~~human RGS8~~ and ~~activated Gi alpha 3===~~

==Disease==

[[http://www.uniprot.org/uniprot/GNAI3_HUMAN GNAI3_HUMAN]] Defects in GNAI3 are the cause of auriculocondylar syndrome 1 (ARCND1) [MIM:[http://omim.org/entry/602483 602483]]. ARCND1 is an autosomal dominant craniofacial malformation syndrome characterized by variable mandibular anomalies, including mild to severe micrognathia, temporomandibular joint ankylosis, cleft palate, and a characteristic ear malformation that consists of separation of the lobule from the external ear, giving the appearance of a question mark (question-mark ear). Other frequently described features include prominent cheeks, cupped and posteriorly rotated ears, preauricular tags, and microstomia.<ref>PMID:22560091</ref>

~~{{ABSTRACT_PUBMED_18434541}}~~

==Function==

[[http://www.uniprot.org/uniprot/GNAI3_HUMAN GNAI3_HUMAN]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(k) is the stimulatory G protein of receptor-regulated K(+) channels. The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> [[http://www.uniprot.org/uniprot/RGS8_HUMAN RGS8_HUMAN]] Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Preferentially binds to G(o)-alpha and G(i)-alpha-3 (By similarity).

==About this Structure==

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==Reference==

[[Category: Homo sapiens]]

[[Category: Arrowsmith, C H.]]

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@@ Line 1: / Line 1: @@
-[[Image:2ode.png|left|200px]]
 {{STRUCTURE_2ode|  PDB=2ode  |  SCENE=  }}
+===Crystal structure of the heterodimeric complex of human RGS8 and activated Gi alpha 3===
+{{ABSTRACT_PUBMED_18434541}}
-===Crystal structure of the heterodimeric complex of human RGS8 and activated Gi alpha 3===
+==Disease==
+[[http://www.uniprot.org/uniprot/GNAI3_HUMAN GNAI3_HUMAN]] Defects in GNAI3 are the cause of auriculocondylar syndrome 1 (ARCND1) [MIM:[http://omim.org/entry/602483 602483]]. ARCND1 is an autosomal dominant craniofacial malformation syndrome characterized by variable mandibular anomalies, including mild to severe micrognathia, temporomandibular joint ankylosis, cleft palate, and a characteristic ear malformation that consists of separation of the lobule from the external ear, giving the appearance of a question mark (question-mark ear). Other frequently described features include prominent cheeks, cupped and posteriorly rotated ears, preauricular tags, and microstomia.<ref>PMID:22560091</ref>
-{{ABSTRACT_PUBMED_18434541}}
+==Function==
+[[http://www.uniprot.org/uniprot/GNAI3_HUMAN GNAI3_HUMAN]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(k) is the stimulatory G protein of receptor-regulated K(+) channels. The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> [[http://www.uniprot.org/uniprot/RGS8_HUMAN RGS8_HUMAN]] Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Preferentially binds to G(o)-alpha and G(i)-alpha-3 (By similarity).
 ==About this Structure==
@@ Line 11: / Line 13: @@
 ==Reference==
-<ref group="xtra">PMID:018434541</ref><references group="xtra"/>
+<ref group="xtra">PMID:018434541</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Arrowsmith, C H.]]