2kl7: Difference between revisions

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[[~~Image~~:2kl7.~~png|left|200px~~]]

==Solution NMR Structure of the EGF-like 1 Domain of Human Fibulin-4. Northeast Structural Genomics Target HR6275==

== Structural highlights ==

<table><tr><td colspan='2'>[[2kl7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KL7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KL7 FirstGlance]. <br>

</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EFEMP2, FBLN4, UNQ200/PRO226 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>

<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kl7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kl7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kl7 RCSB], [http://www.ebi.ac.uk/pdbsum/2kl7 PDBsum], [http://www.topsan.org/Proteins/NESGC/2kl7 TOPSAN]</span></td></tr>

<table>

== Disease ==

[[http://www.uniprot.org/uniprot/FBLN4_HUMAN FBLN4_HUMAN]] Autosomal recessive cutis laxa type 1;Lethal arteriopathy syndrome due to Fibulin-4 deficiency. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:16685658</ref> <ref>PMID:17937443</ref> <ref>PMID:19664000</ref>

== Function ==

~~{{STRUCTURE_2kl7| PDB~~=~~2kl7 | SCENE~~= }}

== Evolutionary Conservation ==

[[Image:Consurf_key_small.gif|200px|right]]

==~~=Solution NMR Structure of the EGF-like 1 Domain of Human Fibulin-4~~. ~~Northeast Structural Genomics Target HR6275===~~

Check<jmol>

<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kl/2kl7_consurf.spt"</scriptWhenChecked>

=~~=About this Structure==~~

<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>

~~[[2kl7]] is a 1 chain~~ structure ~~with sequence from~~ [http://en.~~wikipedia~~.~~org/wiki~~/~~Homo_sapiens Homo sapiens~~]. ~~Full experimental information is~~ available from [http://~~oca~~.~~weizmann~~.ac.il/~~oca-bin~~/~~ocashort~~?id=~~2KL7 OCA~~].

<text>to colour the structure by Evolutionary Conservation</text>

</jmolCheckbox>

</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Anderson, S.]]

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-[[Image:2kl7.png|left|200px]]
+==Solution NMR Structure of the EGF-like 1 Domain of Human Fibulin-4. Northeast Structural Genomics Target HR6275==
+<StructureSection load='2kl7' size='340' side='right' caption='[[2kl7]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2kl7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KL7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KL7 FirstGlance]. <br>
+</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EFEMP2, FBLN4, UNQ200/PRO226 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
+<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kl7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kl7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kl7 RCSB], [http://www.ebi.ac.uk/pdbsum/2kl7 PDBsum], [http://www.topsan.org/Proteins/NESGC/2kl7 TOPSAN]</span></td></tr>
+<table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/FBLN4_HUMAN FBLN4_HUMAN]] Autosomal recessive cutis laxa type 1;Lethal arteriopathy syndrome due to Fibulin-4 deficiency. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:16685658</ref> <ref>PMID:17937443</ref> <ref>PMID:19664000</ref>
+== Function ==
-{{STRUCTURE_2kl7|  PDB=2kl7  |  SCENE=  }}
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
-===Solution NMR Structure of the EGF-like 1 Domain of Human Fibulin-4. Northeast Structural Genomics Target HR6275===
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kl/2kl7_consurf.spt"</scriptWhenChecked>
-==About this Structure==
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-[[2kl7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KL7 OCA].
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+<div style="clear:both"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
 [[Category: Anderson, S.]]