1wap: Difference between revisions
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[[Image:1wap.jpg|left|200px]] | [[Image:1wap.jpg|left|200px]] | ||
'''TRP RNA-BINDING ATTENUATION PROTEIN IN COMPLEX WITH L-TRYPTOPHAN''' | {{Structure | ||
|PDB= 1wap |SIZE=350|CAPTION= <scene name='initialview01'>1wap</scene>, resolution 1.8Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene> | |||
|ACTIVITY= | |||
|GENE= MTRB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis]) | |||
}} | |||
'''TRP RNA-BINDING ATTENUATION PROTEIN IN COMPLEX WITH L-TRYPTOPHAN''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1WAP is a [ | 1WAP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WAP OCA]. | ||
==Reference== | ==Reference== | ||
The structure of trp RNA-binding attenuation protein., Antson AA, Otridge J, Brzozowski AM, Dodson EJ, Dodson GG, Wilson KS, Smith TM, Yang M, Kurecki T, Gollnick P, Nature. 1995 Apr 20;374(6524):693-700. PMID:[http:// | The structure of trp RNA-binding attenuation protein., Antson AA, Otridge J, Brzozowski AM, Dodson EJ, Dodson GG, Wilson KS, Smith TM, Yang M, Kurecki T, Gollnick P, Nature. 1995 Apr 20;374(6524):693-700. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7715723 7715723] | ||
[[Category: Bacillus subtilis]] | [[Category: Bacillus subtilis]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: Gollnick, P.]] | [[Category: Gollnick, P.]] | ||
[[Category: TRP]] | [[Category: TRP]] | ||
[[Category: bacillus | [[Category: bacillus subtili]] | ||
[[Category: trp operon]] | [[Category: trp operon]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:54:31 2008'' | ||
Revision as of 12:54, 20 March 2008
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| 1wap, resolution 1.8Å | |||||||||||||
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| Ligands: | TRP | ||||||||||||
| Gene: | MTRB (Bacillus subtilis) | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
TRP RNA-BINDING ATTENUATION PROTEIN IN COMPLEX WITH L-TRYPTOPHAN
Overview
The crystal structure of the trp RNA-binding attenuation protein of Bacclius subtilis solved at 1.8 A resolution reveals a novel structural arrangement in which the eleven subunits are stabilized through eleven intersubunit beta-sheets to form a beta-wheel with a large central hole. The nature of the binding of L-tryptophan in clefts between adjacent beta-sheets in the beta-wheel suggests that this binding induces conformational changes in the flexible residues 25-33 and 49-52. It is argued that upon binding, the messenger RNA target forms a matching circle in which eleven U/GAG repeats are bound to the surface of the protein ondecamer modified by the binding of L-tryptophan.
About this Structure
1WAP is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.
Reference
The structure of trp RNA-binding attenuation protein., Antson AA, Otridge J, Brzozowski AM, Dodson EJ, Dodson GG, Wilson KS, Smith TM, Yang M, Kurecki T, Gollnick P, Nature. 1995 Apr 20;374(6524):693-700. PMID:7715723
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