1wax: Difference between revisions

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[[Image:1wax.gif|left|200px]]~~<br /><applet load~~="1wax~~" size~~="350~~" color~~=~~"white" frame~~=~~"true" align="right" spinBox="true"~~

[[Image:1wax.gif|left|200px]]

~~caption="~~1wax, resolution 2.20Å" />

'''PROTEIN TYROSINE PHOSPHATASE 1B WITH ACTIVE SITE INHIBITOR'''~~<br />~~

{{Structure

|PDB= 1wax |SIZE=350|CAPTION= <scene name='initialview01'>1wax</scene>, resolution 2.20Å

|SITE= <scene name='pdbsite=AC1:Lo1+Binding+Site+For+Chain+A'>AC1</scene>

|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=LO1:[[4-(AMINOMETHYL)PHENYL]AMINO]OXO-ACETIC ACID,'>LO1</scene>

|ACTIVITY= [http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48]

|GENE=

}}

'''PROTEIN TYROSINE PHOSPHATASE 1B WITH ACTIVE SITE INHIBITOR'''

==Overview==

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==About this Structure==

1WAX is a [~~http://en.wikipedia.org/wiki/Single_protein~~ Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=LO1:'>LO1</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] Known structural/functional Site: <scene name='pdbsite=AC1:Lo1+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WAX OCA].

1WAX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WAX OCA].

==Reference==

Fragment-based lead discovery using X-ray crystallography., Hartshorn MJ, Murray CW, Cleasby A, Frederickson M, Tickle IJ, Jhoti H, J Med Chem. 2005 Jan 27;48(2):403-13. PMID:[http://~~ispc~~.~~weizmann~~.ac.~~il/~~/~~pmbin~~/~~getpm?pmid=~~15658854 15658854]

Fragment-based lead discovery using X-ray crystallography., Hartshorn MJ, Murray CW, Cleasby A, Frederickson M, Tickle IJ, Jhoti H, J Med Chem. 2005 Jan 27;48(2):403-13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15658854 15658854]

[[Category: Homo sapiens]]

[[Category: Protein-tyrosine-phosphatase]]

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[[Category: acetylation]]

[[Category: hydrolase]]

[[Category: ~~inhibitors~~]]

[[Category: inhibitor]]

[[Category: phosphorylation]]

[[Category: protein tyrosine phosphatase]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu ~~Feb 21 15~~:42:19 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:54:32 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1wax.gif|left|200px]]<br /><applet load="1wax" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1wax.gif|left|200px]]
-caption="1wax, resolution 2.20&Aring;" />
-'''PROTEIN TYROSINE PHOSPHATASE 1B WITH ACTIVE SITE INHIBITOR'''<br />
+ {{Structure
+|PDB= 1wax |SIZE=350|CAPTION= <scene name='initialview01'>1wax</scene>, resolution 2.20&Aring;
+|SITE= <scene name='pdbsite=AC1:Lo1+Binding+Site+For+Chain+A'>AC1</scene>
+|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=LO1:[[4-(AMINOMETHYL)PHENYL]AMINO]OXO-ACETIC ACID,'>LO1</scene>
+|ACTIVITY= [http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48]
+|GENE=
+}}
+'''PROTEIN TYROSINE PHOSPHATASE 1B WITH ACTIVE SITE INHIBITOR'''
 ==Overview==
@@ Line 10: / Line 19: @@
 ==About this Structure==
-WAX is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=LO1:'>LO1</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] Known structural/functional Site: <scene name='pdbsite=AC1:Lo1+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WAX OCA].
+WAX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WAX OCA].
 ==Reference==
-Fragment-based lead discovery using X-ray crystallography., Hartshorn MJ, Murray CW, Cleasby A, Frederickson M, Tickle IJ, Jhoti H, J Med Chem. 2005 Jan 27;48(2):403-13. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15658854 15658854]
+Fragment-based lead discovery using X-ray crystallography., Hartshorn MJ, Murray CW, Cleasby A, Frederickson M, Tickle IJ, Jhoti H, J Med Chem. 2005 Jan 27;48(2):403-13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15658854 15658854]
 [[Category: Homo sapiens]]
 [[Category: Protein-tyrosine-phosphatase]]
@@ Line 27: / Line 36: @@
 [[Category: acetylation]]
 [[Category: hydrolase]]
-[[Category: inhibitors]]
+[[Category: inhibitor]]
 [[Category: phosphorylation]]
 [[Category: protein tyrosine phosphatase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:42:19 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:54:32 2008''