1wbu: Difference between revisions

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[[Image:1wbu.gif|left|200px]]~~<br /><applet load~~="1wbu~~" size~~="350~~" color~~=~~"white" frame~~=~~"true" align="right" spinBox="true"~~

[[Image:1wbu.gif|left|200px]]

~~caption="~~1wbu, resolution 1.9Å" />

'''FRAGMENT BASED LEAD DISCOVERY USING CRYSTALLOGRAPHY'''~~<br />~~

{{Structure

|PDB= 1wbu |SIZE=350|CAPTION= <scene name='initialview01'>1wbu</scene>, resolution 1.9Å

|SITE= <scene name='pdbsite=AC1:Wbu+Binding+Site+For+Chain+B'>AC1</scene>

|LIGAND= <scene name='pdbligand=WBU:5-AMINO-1H-PYRIMIDINE-2,4-DIONE'>WBU</scene>

|ACTIVITY= [http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5]

|GENE=

}}

'''FRAGMENT BASED LEAD DISCOVERY USING CRYSTALLOGRAPHY'''

==Overview==

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==About this Structure==

1WBU is a [~~http://en.wikipedia.org/wiki/Single_protein~~ Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with <scene name='pdbligand=WBU:'>WBU</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] Known structural/functional Site: <scene name='pdbsite=AC1:Wbu+Binding+Site+For+Chain+B'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WBU OCA].

1WBU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WBU OCA].

==Reference==

Fragment-based lead discovery using X-ray crystallography., Hartshorn MJ, Murray CW, Cleasby A, Frederickson M, Tickle IJ, Jhoti H, J Med Chem. 2005 Jan 27;48(2):403-13. PMID:[http://~~ispc~~.~~weizmann~~.ac.~~il/~~/~~pmbin~~/~~getpm?pmid=~~15658854 15658854]

Fragment-based lead discovery using X-ray crystallography., Hartshorn MJ, Murray CW, Cleasby A, Frederickson M, Tickle IJ, Jhoti H, J Med Chem. 2005 Jan 27;48(2):403-13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15658854 15658854]

[[Category: Bos taurus]]

[[Category: Pancreatic ribonuclease]]

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[[Category: ribonuclease]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:54:56 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1wbu.gif|left|200px]]<br /><applet load="1wbu" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1wbu.gif|left|200px]]
-caption="1wbu, resolution 1.9&Aring;" />
-'''FRAGMENT BASED LEAD DISCOVERY USING CRYSTALLOGRAPHY'''<br />
+ {{Structure
+|PDB= 1wbu |SIZE=350|CAPTION= <scene name='initialview01'>1wbu</scene>, resolution 1.9&Aring;
+|SITE= <scene name='pdbsite=AC1:Wbu+Binding+Site+For+Chain+B'>AC1</scene>
+|LIGAND= <scene name='pdbligand=WBU:5-AMINO-1H-PYRIMIDINE-2,4-DIONE'>WBU</scene>
+|ACTIVITY= [http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5]
+|GENE=
+}}
+'''FRAGMENT BASED LEAD DISCOVERY USING CRYSTALLOGRAPHY'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-WBU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with <scene name='pdbligand=WBU:'>WBU</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] Known structural/functional Site: <scene name='pdbsite=AC1:Wbu+Binding+Site+For+Chain+B'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WBU OCA].
+WBU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WBU OCA].
 ==Reference==
-Fragment-based lead discovery using X-ray crystallography., Hartshorn MJ, Murray CW, Cleasby A, Frederickson M, Tickle IJ, Jhoti H, J Med Chem. 2005 Jan 27;48(2):403-13. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15658854 15658854]
+Fragment-based lead discovery using X-ray crystallography., Hartshorn MJ, Murray CW, Cleasby A, Frederickson M, Tickle IJ, Jhoti H, J Med Chem. 2005 Jan 27;48(2):403-13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15658854 15658854]
 [[Category: Bos taurus]]
 [[Category: Pancreatic ribonuclease]]
@@ Line 27: / Line 36: @@
 [[Category: ribonuclease]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:42:37 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:54:56 2008''