1gzt: Difference between revisions
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==Overview== | ==Overview== | ||
Pseudomonas aeruginosa galactose- and fucose-binding lectins (PA-IL and, PA-IIL) contribute to the virulence of this pathogenic bacterium, which is, a major cause of morbidity and mortality in cystic fibrosis patients. The, crystal structure of PA-IIL in complex with fucose reveals a tetrameric, structure. Each monomer displays a nine-stranded, antiparallel b-sandwich, arrangement and contains two close calcium cations that mediate the, binding of fucose in a recognition mode unique among carbohydrate-protein, interactions. Experimental binding studies, together with theoretical, docking of fucose-containing oligosaccharides, are consistent with the, assumption that antigens of the Lewis a (Le(a)) series may be the, preferred ligands of this lectin. Precise knowledge of the . | Pseudomonas aeruginosa galactose- and fucose-binding lectins (PA-IL and, PA-IIL) contribute to the virulence of this pathogenic bacterium, which is, a major cause of morbidity and mortality in cystic fibrosis patients. The, crystal structure of PA-IIL in complex with fucose reveals a tetrameric, structure. Each monomer displays a nine-stranded, antiparallel b-sandwich, arrangement and contains two close calcium cations that mediate the, binding of fucose in a recognition mode unique among carbohydrate-protein, interactions. Experimental binding studies, together with theoretical, docking of fucose-containing oligosaccharides, are consistent with the, assumption that antigens of the Lewis a (Le(a)) series may be the, preferred ligands of this lectin. Precise knowledge of the lectin-binding, site should allow a better design of new antibacterial-adhesion, prophylactics. | ||
==About this Structure== | ==About this Structure== | ||
1GZT is a | 1GZT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa] with FUC and CA as [http://en.wikipedia.org/wiki/ligands ligands]. Structure known Active Site: FUA. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GZT OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: sugar-binding protein]] | [[Category: sugar-binding protein]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 12:52:48 2007'' | ||
