2odq: Difference between revisions
From Proteopedia
Jump to navigationJump to search
m Protected "2odq" [edit=sysop:move=sysop] |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_2odq| PDB=2odq | SCENE= }} | {{STRUCTURE_2odq| PDB=2odq | SCENE= }} | ||
===Complement component C2a, the catalytic fragment of C3- and C5-convertase of human complement=== | |||
{{ABSTRACT_PUBMED_17234210}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/CO2_HUMAN CO2_HUMAN]] Defects in C2 are the cause of complement component 2 deficiency (C2D) [MIM:[http://omim.org/entry/217000 217000]]. A deficiency of the complement classical pathway associated with the development of autoimmune disorders, mainly systemic lupus erythematosus. Skin and joint manifestations are common and renal disease is relatively rare. Patients with complement component 2 deficiency are also reported to have recurrent or invasive infections.<ref>PMID:8621452</ref><ref>PMID:9670930</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CO2_HUMAN CO2_HUMAN]] Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor 4b to generate the C3 or C5 convertase. | |||
==About this Structure== | ==About this Structure== | ||
| Line 11: | Line 13: | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:017234210</ref><references group="xtra"/> | <ref group="xtra">PMID:017234210</ref><references group="xtra"/><references/> | ||
[[Category: Classical-complement-pathway C3/C5 convertase]] | [[Category: Classical-complement-pathway C3/C5 convertase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
