2ocp: Difference between revisions
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{{STRUCTURE_2ocp| PDB=2ocp | SCENE= }} | {{STRUCTURE_2ocp| PDB=2ocp | SCENE= }} | ||
===Crystal Structure of Human Deoxyguanosine Kinase=== | |||
{{ABSTRACT_PUBMED_11427893}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/DGUOK_HUMAN DGUOK_HUMAN]] Defects in DGUOK are the cause of mitochondrial DNA depletion syndrome type 3 (MTDPS3) [MIM:[http://omim.org/entry/251880 251880]]. A disorder characterized by onset in infancy of progressive liver failure, hypoglycemia, increased lactate in body fluids, and neurologic abnormalities including hypotonia, encephalopathy, peripheral neuropathy. Affected tissues show both decreased activity of the mtDNA-encoded respiratory chain complexes and mtDNA depletion.<ref>PMID:12205643</ref><ref>PMID:15639197</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/DGUOK_HUMAN DGUOK_HUMAN]] Required for the phosphorylation of several deoxyribonucleosides and certain nucleoside analogs widely employed as antiviral and chemotherapeutic agents.<ref>PMID:8706825</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:011427893</ref><references group="xtra"/> | <ref group="xtra">PMID:011427893</ref><references group="xtra"/><references/> | ||
[[Category: Deoxyguanosine kinase]] | [[Category: Deoxyguanosine kinase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
